对称宫内生长迟缓并非对称:妊娠中期和新生儿18三体的器官特异性体重缺陷。

Fetal therapy Pub Date : 1989-01-01 DOI:10.1159/000263432
M P Johnson, M Barr, F Qureshi, A Drugan, M I Evans
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引用次数: 9

摘要

预测正常胎儿生长的模型准确性有限。异常增长的问题更大。我们开发了一个基于观察到的身体和大脑重量的数学建模系统来研究妊娠中期18三体胎儿的生长模式。基于三度多项式的分析使用观察到的胎儿身体和大脑重量来生成各种器官系统的预测重量,从而可以对不同胎儿体重和胎龄的生长模式进行比较研究。我们的数据表明,以前被称为与非整倍体胎儿相关的对称宫内生长迟缓实际上是一种不对称的模式,它在本质上是动态的,并可能在怀孕过程中发生变化。
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Symmetrical intrauterine growth retardation is not symmetrical: organ-specific gravimetric deficits in midtrimester and neonatal trisomy 18.

Models to predict normal fetal growth have been of limited accuracy. Abnormal growth is even more problematic. We have developed a mathematical modeling system based on observed body and brain weights to study fetal growth patterns in midgestational trisomy 18 fetuses. Third-degree polynomial-based analysis using observed fetal body and brain weights to generate predicted weights for various organ systems allows for the comparative study of growth patterns at various fetal weights and gestational ages. Our data suggest that what has been previously called symmetrical intrauterine growth retardation associated with aneuploid fetuses is really an asymmetrical pattern that is dynamic in nature and may change through the course of pregnancy.

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