在Al-Hilla市糖尿病和内分泌中心就诊的2型糖尿病患者样本中维生素D3水平的评估

Q4 Biochemistry, Genetics and Molecular Biology Journal of Biomolecular Techniques Pub Date : 2023-09-30 DOI:10.51173/jt.v5i3.1452
None Ahmed Mahdi Habeeb, None Atta Ah Mousa Al-Sarray, None Ali Hussein Al Hafidh, None Rafah Sabah Barrak, None Afraa Brahim
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引用次数: 0

摘要

维生素D主要以两种形式存在于食物中:胆钙化醇(维生素D3)和麦角钙化醇(维生素D2),其中维生素D3是脂溶性维生素。这是钙稳态和维持各种组织正常功能所必需的。人类从饮食或太阳紫外线B辐射中获取维生素D。除了众所周知的对骨骼健康的影响,维生素D一直被假设在各种疾病状态和健康状况中发挥作用,例如心血管疾病和2型糖尿病。使用Cobas E 411设备上的维生素D Total III试剂盒评估2型糖尿病患者的维生素D3浓度。总共招募了300人,其中150名2型糖尿病患者作为病例,150名相同性别和年龄的健康志愿者作为对照组。男女都有代表,年龄在30 - 79岁之间。数据收集时间为5个月,从2022年11月开始至2023年4月。采用SPSS-28统计软件包对数据进行分析,并采用卡方检验评价维生素D、T2DM和对照组之间的关系。数据以简单的频率、百分比、平均值、标准差和范围测量提供。2型糖尿病患者的平均±SD年龄为55.4±10.1岁,对照组的平均±SD年龄为55.3±10.0岁。T2DM的社会人口学特征和参与者控制。年龄、学校水平(P = 0.0001)、婚姻状况(P = 0.008)等变量之间存在显著的相关性。T2DM组BMI: mean±SD(29.69±5.14)高于对照组BMI: mean±SD(24.41±1.95),腰高比高于对照组BMI: mean±SD(0.527±0.046),说明T2DM组在水平上的平均值±SD(0.483±0.019)大于对照组(P = 0.0001);T2DM患者有维生素D3缺乏和不足(分别为38.7%和33.3%),而对照组有维生素D3缺乏和不足(分别为28.7%和30.0%)。研究发现,维生素D3水平低和2型糖尿病患者之间存在显著差异,缺乏维生素D3与患2型糖尿病的风险增加有关。
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Assessment of Vitamin D3 Level Among a Sample of Type 2 Diabetic Patients Attending Diabetes and Endocrinology Center in Al-Hilla City
Vitamin D is found in foods in two primary forms: cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2), with vitamin D3 being a fat-soluble vitamin. that is necessary for calcium homeostasis and the maintenance of proper function in a variety of tissues. Humans get vitamin D from their diets or from being exposed to ultraviolet B radiation from the sun. Aside from its well-known effects on bone health, vitamin D has been hypothesized to play a role in various disease states and health situations, such as cardiovascular disease and type 2 diabetes. To assess vitamin D3 concentration in patients with type 2 diabetes, using the Vitamin D Total III kit on the Cobas E 411 device. A total of 300 people were recruited, with 150 people suffering from type 2 diabetes serving as cases and 150 healthy volunteers of the same gender and age being used as the control group. Both genders were represented, with an age group between 30 – 79 years. The collection of data lasts for five months, beginning Started in November 2022 to April 2023. The data was analyzed with the readily available statistical package SPSS-28, and Chi-square tests were used to evaluate the relationship among vitamin D, T2DM, and control. Data were provided in simple frequency, percentage, mean, standard deviation, and range measures. Type 2 diabetes patients' mean ± SD ages were 55.4 ± 10.1, while controls had a mean ± SD of age of 55.3 ± 10.0. the sociodemographic features of T2DM and participant control. Shows A statistically significant association was found in the variables of age groups, school level (P = 0.0001), and marital status (P = 0.008). The BMI: mean ± SD (29.69 ± 5.14) of T2DM was higher than the BMI: mean ± SD (24.41 ± 1.95) of controls, as well as the waist-to-height ratio, which showed that the mean ± SD (0.527 ± 0.046) of T2DM was greater than the control mean ± SD (0.483 ± 0.019) at level (P = 0.0001); T2DM patients had deficient and insufficient vitamin D3 levels (38.7% and 33.3%, respectively), whereas controls had deficient and insufficient vitamin D3 levels (28.7% and 30.0%, respectively). It was found that there is a significant difference between low vitamin D3 levels and individuals with type 2 diabetes, and A lack of vitamin D3 is related to an increased risk of developing T2DM.
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来源期刊
Journal of Biomolecular Techniques
Journal of Biomolecular Techniques Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
2.50
自引率
0.00%
发文量
9
期刊介绍: The Journal of Biomolecular Techniques is a peer-reviewed publication issued five times a year by the Association of Biomolecular Resource Facilities. The Journal was established to promote the central role biotechnology plays in contemporary research activities, to disseminate information among biomolecular resource facilities, and to communicate the biotechnology research conducted by the Association’s Research Groups and members, as well as other investigators.
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