& lt; i>幽门螺杆菌pylori< / i>免疫性血小板减少症患儿的感染

S. M. Ragab, M. A. El-Hawy, S. M. Awad, W. A. Soliman, A. A. Mahmoud
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引用次数: 0

摘要

目的:探讨儿童和青少年幽门螺杆菌感染与免疫性血小板减少症的关系。免疫性血小板减少症(ITP)是儿童常见的出血性疾病。幽门螺杆菌是一种广泛存在的生物,约占全球人口的50%。幽门螺杆菌感染与慢性特发性血小板减少性紫癜有明显的相关性。在2021年6月至2022年6月期间,对从Menoufia大学医院儿科血液科招募的95名ITP患者进行了横断面研究。患者年龄在3.5 - 7.5岁之间。其中55人为男性,40人为女性。该研究得到了Menoufia大学医学院伦理委员会的批准。在研究的ITP患儿中,62例(65.3%)粪便幽门螺杆菌抗原阳性,33例(34.7%)粪便幽门螺杆菌抗原阴性。幽门螺杆菌阳性和幽门螺杆菌阴性患者入院时出血程度有显著差异;51例(82.3%)幽门螺旋杆菌阳性患者出现3级出血,35例(56.5%)出现皮肤和牙龈出血,16例(25.8%)出现皮肤出血和鼻出血。幽门螺杆菌阴性患者的康复率为78.8%,幽门螺杆菌阳性患者的康复率为22.6%,差异有统计学意义。幽门螺杆菌治疗后,幽门螺杆菌阳性患者血小板计数明显升高。ITP患儿幽门螺杆菌感染率为65.3%。幽门螺杆菌治疗后,幽门螺杆菌阳性ITP患儿血小板计数明显升高。
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<i>Helicobacter pylori</i> infection in children with immune thrombocytopenia
To detect the association between Helicobacter pylori (H. pylori) infection and immune thrombocytopenia in children and adolescents. Immune thrombocytopenia (ITP) is a common bleeding disorder in childhood. H. pylori is a widespread organism that is present in about 50% of the global population. There is an obvious relation between helicobacter pylori infection and chronic idiopathic thrombocytopenic purpura. A cross-sectional study was conducted in 95 patients with ITP who were recruited from the Hematology Unit, Department of Pediatrics, Menoufia University Hospital in the period from June 2021 to June 2022. The age of the patients ranged between 3.5 and 7.5 years. Fifty-five of them were males and 40 were females. The study was approved by the Ethical Committee of the Faculty of Medicine, Menoufia University. Out of the studied ITP children, 62 (65.3%) were positive for H. pylori antigen in stool, and 33 (34.7%) were negative. There was a significant difference between H. pylori-positive and H. pylori-negative patients regarding the grade of bleeding at presentation; 51 (82.3%) H. pylori-positive patients presented with grade 3 bleeding, 35 (56.5%) of them presented with skin and gum bleeding, 16 (25.8%) presented with skin bleeding and epistaxis. There was a statistically significant difference in the rate of recovery between H. pylorinegative patients (78.8%) and H. pylori-positive patients (22.6%). There was a significant rise in the platelet count in H. pylori-positive patients after the treatment of H. pylori. The prevalence of H. pylori infection in ITP pediatric patients was 65.3%. There was a significant rise in the platelet count in H. pylori-positive ITP children after the treatment of H. pylori.
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来源期刊
Pediatric Hematology/Oncology and Immunopathology
Pediatric Hematology/Oncology and Immunopathology Medicine-Pediatrics, Perinatology and Child Health
CiteScore
0.40
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发文量
49
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