预防2型糖尿病:间歇性禁食的作用

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Diabetology Pub Date : 2023-11-13 DOI:10.3390/diabetology4040044
Bright Test, Jay H. Shubrook
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引用次数: 0

摘要

尽管在治疗选择和对病理生理学的理解方面取得了进展,但2型糖尿病仍然是全球最昂贵和最有害的慢性疾病之一。目前的指导方针鼓励医生打一场艰苦的战斗,并对临床惰性推动的潜伏疾病状态做出反应。作者完成了PubMed、ScienceDirect和NIH的文献检索,检索了间歇性禁食、2型糖尿病和前驱糖尿病,并排除了与宗教禁食相关的研究。越来越多的证据表明,间歇性禁食可以帮助减轻体重,减少肝脏脂肪变性,降低空腹血糖等生物标志物水平,同时改善胰岛素抵抗。如果将间歇性禁食纳入具有2型糖尿病危险因素的患者的生活中,可能被证明是预防这种潜在疾病的一种经济有效的工具。本临床综述检查了支持实施这种生活方式以预防2型糖尿病发病或恶化的现有证据,以及医生必须克服的障碍,以便自信地给患者开这种处方。
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Prevention of Type 2 Diabetes: The Role of Intermittent Fasting
Despite the progress in treatment options and improved understanding of pathophysiology, type 2 diabetes remains one of the costliest and most harmful global chronic diseases. The current guidelines encourage physicians to fight an uphill battle and react to an incubated disease state that has been propelled forward by clinical inertia. The authors completed a literature search of PubMed, ScienceDirect, and NIH, searching with the terms intermittent fasting, type 2 diabetes, and prediabetes, and excluded studies related to religion-based fasting. There is emerging evidence that intermittent fasting could be an option to aid in weight loss, reduce hepatic steatosis, and lower the level of biomarkers such as fasting glucose while improving insulin resistance. If incorporated into the lives of patients with risk factors for type 2 diabetes, intermittent fasting could prove to be a cost-effective and efficient tool for preventing this insidious disease. This clinical review examines current evidence supporting the implementation of this lifestyle to prevent the onset or exacerbation of type 2 diabetes and the hurdles that must still be overcome for physicians to confidently prescribe this to their patients.
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