Duhok个体中TP53 (Arg72Pro) rs1042522 C>G多态性与结直肠癌易感性的关系

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This study was conducted to estimate the distribution of colorectal cancer within age groups, Tumor type, Nodal state, and Duck stage of individual also to investigate the distribution of TP53 Arg72Pro SNPs genotype in colorectal cancer, and determine whether TP53 Arg72Pro polymorphism is a possible relevance in susceptibility to colorectal cancer using RFLP-PCR analysis. Results: The present study shows there were no statistically significant differences between the different age groups and Dukes states with gender. Additionally, tumor types and nodal states (either positive or negative) of colorectal cancer were significantly different with gender. Also, this study revealed that 10 (20.0%) colorectal cancer patients had a 152 bp undigested PCR product fragment representing homozygotes for proline, 8 (16.0%) had two 50 and 102 bp fragments representing homozygotes for arginine, and 32 (64.0%) had three 50, 102, and 152 bp fragments representing heterozygotes for proline. 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摘要

背景与目的:TP53基因编码一类重要的细胞周期和肿瘤抑制因子,在维持基因组稳定性中起关键作用。据报道,TP53 Arg72Pro (rs1042522 C>G)多态性与几种成人癌症的风险相关。本研究的目的是探讨TP53 Arg72Pro多态性与结直肠癌的可能关系,并探讨其与个体的年龄、肿瘤类型、结状态和Duck分期的相关性。患者和方法:本研究涉及50例结直肠癌患者(男性25例,女性25例)。本研究旨在估计结直肠癌在个体的年龄、肿瘤类型、淋巴结状态和Duck分期中的分布,探讨TP53 Arg72Pro snp基因型在结直肠癌中的分布,并利用RFLP-PCR分析TP53 Arg72Pro多态性是否可能与结直肠癌易感性相关。结果:本研究显示不同年龄组和不同性别的Dukes州之间无统计学差异。此外,结直肠癌的肿瘤类型和淋巴结状态(阳性或阴性)在性别上也存在显著差异。此外,本研究发现10例(20.0%)结直肠癌患者有152 bp未消化的PCR产物片段代表脯氨酸纯合子,8例(16.0%)有2个50和102 bp的片段代表精氨酸纯合子,32例(64.0%)有3个50、102和152 bp的片段代表脯氨酸杂合子。对照基因型结果显示,14人(28.0%)有152 bp的片段为脯氨酸纯合子,20人(40.0%)有2个片段为精氨酸纯合子,14人(28.0%)有3个条带为密码子72的杂合子。结论:结直肠癌男性患者中arg72等位基因和pro72等位基因的频率与对照组中arg72等位基因和pro72等位基因的频率无显著差异(P>0.05)。在雌性中,arg72等位基因和pro72等位基因的频率有显著差异(P>0.05)。
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The association of TP53 (Arg72Pro) rs1042522 C>G polymorphism and colorectal cancer susceptibility in Duhok individuals
Background and aim: The TP53 gene encodes an important class of cell cycle and tumor-suppressing factors that play critical roles in maintaining genomic stability. The TP53 Arg72Pro (rs1042522 C>G) polymorphism has been reported to be associated with the risk of several types of adult cancers. Objective of this study was to investigate the possible association between TP53 Arg72Pro polymorphism with colorectal cancer and to examine its correlation with age groups, Tumor type, Nodal state, and Duck stage of individual. Patients and methods: The study involved 50 patients with colorectal cancer (25 males and 25 females). This study was conducted to estimate the distribution of colorectal cancer within age groups, Tumor type, Nodal state, and Duck stage of individual also to investigate the distribution of TP53 Arg72Pro SNPs genotype in colorectal cancer, and determine whether TP53 Arg72Pro polymorphism is a possible relevance in susceptibility to colorectal cancer using RFLP-PCR analysis. Results: The present study shows there were no statistically significant differences between the different age groups and Dukes states with gender. Additionally, tumor types and nodal states (either positive or negative) of colorectal cancer were significantly different with gender. Also, this study revealed that 10 (20.0%) colorectal cancer patients had a 152 bp undigested PCR product fragment representing homozygotes for proline, 8 (16.0%) had two 50 and 102 bp fragments representing homozygotes for arginine, and 32 (64.0%) had three 50, 102, and 152 bp fragments representing heterozygotes for proline. The results of control genotypes showed 14 (28.0%) people with a fragment of 152 bp indicating homozygotes proline, 20 (40.0%) with two fragments representing homozygotes arginine, and 14 (28.0%) with three bands showing heterozygotes for codon 72. Conclusion: No substantial differences (P>0.05) between the frequency of Arg72allele and Pro72allele in colorectal cancer -affected males as opposed to the frequency of Arg72allele and Pro72allele in the control groups. In relation to the frequency of Arg72allele and Pro72allele in females, indicates substantial differences (P>0.05).
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