不同妊娠期孕妇的免疫状况

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摘要

本研究旨在评估孕期不同阶段孕妇的免疫状况。在执行纳入和排除标准后,本研究纳入了40名孕妇和40名已婚但未怀孕的健康妇女作为对照组。血清分别取自三个不同妊娠期的孕妇和对照组。检测干扰素γ (IFN-γ)、免疫球蛋白g (IgG) IgA、类风湿因子(RF)、丙二醛(MDA)含量。结果显示,与对照组相比,IFN-γ在妊娠第二和第三个月有统计学意义上的显著降低,在对照组和妊娠第一三个月之间没有显著变化,在妊娠第三个月与妊娠第一三个月相比有统计学意义上的降低。对于总IgG,结果显示IgG水平在妊娠早期较对照组明显下降。与此同时,妊娠晚期IgG水平明显高于妊娠晚期。然而,IgA在妊娠中期较对照组明显升高,而在妊娠晚期较妊娠早期和晚期有所下降。与对照组相比,RF在妊娠1、2个月显著升高,但在统计学上,妊娠3个月与妊娠1、2个月相比显著降低。最后,与对照组相比,MDA水平在所有妊娠期都有所增加。
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Immunological Status of Pregnant Women in Different Trimesters
This investigation done to evaluate the immunological status of pregnant women in different trimesters during pregnancy. After performing inclusion and exclusion criteria, this study included 40 pregnant women and 40 healthy women who had married but were not pregnant as a control group. The serum was obtained from pregnant women in three different trimesters and from control group. Interferon γ (IFN-γ), Immunoglobulin-G (IgG) IgA, Rheumatoid factor (RF) and Malondialdehyde (MDA) were measured. The results demonstrate a statistically significant reduction in IFN-γ with respect to the 2nd and 3rd trimesters in comparison to the control group, with no significant change between the control and 1st trimester and a statistical decrease in the 3rd trimester when compared to the 1st trimester. Regarding the total IgG, the result shows a significant decline in the level of IgG in the 1st trimester in comparison to the control group. At the same time, there is a significant elevation in the level of IgG in the 3rd trimester compared to the 2nd trimester. However, there is a significant increase of IgA in the 2nd trimester in comparison to the control group, meanwhile, its level decreases in the 3rd trimester in comparison to 1st and 2nd trimesters. RF increased significantly in the 1st and 2nd trimesters in comparison to the control group, but statistically, there is a significant decrease in 3rd trimester compared to 1st and 2nd trimesters. Finally, the level of MDA increases in all trimesters compared to the control group.
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