{"title":"干扰素和地塞米松对肿瘤坏死因子有丝分裂活性的调节。","authors":"M Tsujimoto, M Sugiyama, H Adachi","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Effect of interferon (IFN)s on fibroblast growth enhancing activity of tumor necrosis factor (TNF) was examined. IFN-gamma and -beta inhibited TNF-mediated growth stimulation of FS-4 cells. IFNs also inhibited dexamethasone (DEX)-mediated amplification of mitogenic activity of TNF. Significant inhibition was still demonstrable when IFN-gamma was added 2 days after treatment with TNF. On the other hand, no mitogenic activity of TNF was observed when cells were pretreated with IFN-gamma for 6h. These results suggested that interaction between TNF and IFN-gamma might play a role in modulation of some inflammatory processes in vivo.</p>","PeriodicalId":18130,"journal":{"name":"Lymphokine research","volume":"8 2","pages":"99-106"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Modulation of mitogenic activity of tumor necrosis factor by interferons and dexamethasone.\",\"authors\":\"M Tsujimoto, M Sugiyama, H Adachi\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Effect of interferon (IFN)s on fibroblast growth enhancing activity of tumor necrosis factor (TNF) was examined. IFN-gamma and -beta inhibited TNF-mediated growth stimulation of FS-4 cells. IFNs also inhibited dexamethasone (DEX)-mediated amplification of mitogenic activity of TNF. Significant inhibition was still demonstrable when IFN-gamma was added 2 days after treatment with TNF. On the other hand, no mitogenic activity of TNF was observed when cells were pretreated with IFN-gamma for 6h. These results suggested that interaction between TNF and IFN-gamma might play a role in modulation of some inflammatory processes in vivo.</p>\",\"PeriodicalId\":18130,\"journal\":{\"name\":\"Lymphokine research\",\"volume\":\"8 2\",\"pages\":\"99-106\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1989-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lymphokine research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lymphokine research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Modulation of mitogenic activity of tumor necrosis factor by interferons and dexamethasone.
Effect of interferon (IFN)s on fibroblast growth enhancing activity of tumor necrosis factor (TNF) was examined. IFN-gamma and -beta inhibited TNF-mediated growth stimulation of FS-4 cells. IFNs also inhibited dexamethasone (DEX)-mediated amplification of mitogenic activity of TNF. Significant inhibition was still demonstrable when IFN-gamma was added 2 days after treatment with TNF. On the other hand, no mitogenic activity of TNF was observed when cells were pretreated with IFN-gamma for 6h. These results suggested that interaction between TNF and IFN-gamma might play a role in modulation of some inflammatory processes in vivo.
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