111In奥曲肽治疗期间患者特异性计算机自动剂量测定计算

Ioannis Vamvakas, Nefeli Lagopati, Maria Andreou, Marios Sotiropoulos, Athanasios Gatzis, George Limouris, Christos Antypas, Maria Lyra
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引用次数: 0

摘要

本研究的目的是计算22例诊断为肝脏神经内分泌肿瘤并接受111In奥曲肽治疗剂量的患者的吸收剂量。通过肝内导管输注in -111奥曲肽是我院治疗肝细胞癌和神经内分泌肿瘤的常用技术。这种治疗方式的患者特异性剂量计算是基于放射药物输注后立即、通过肝动脉端口以及输注后24和48小时获得的前后闪烁成像图像。考虑计数率、患者体径和源器官大小,对伽马照相机进行校准,以估计源器官的活动。结果显示,肿瘤吸收剂量根据病变大小在2.5 ~ 18.4 mGy/MBq之间。患者特定剂量计算有助于医生优化治疗计划,避免对健康组织产生副作用,并根据治疗结果分配给药剂量。
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Patient specific computer automated dosimetry calculations during therapy with 111In Octreotide

The aim of this study was to calculate the absorbed dose of 22 patients that were diagnosed for neuroendocrine tumours in liver and had received therapeutic dose of 111In octreotide. In-111 Octreotide infusion, via intrahepatic catheterization is well established technique in our Institution in hepatocellular carcinoma and neuroendocrine tumours treatments. The patient specific dosimetry calculations, for this way of treatment, were based on anterior and posterior scintigraphy images that were acquired immediately after radiopharmaceutical infusion, through hepatic arterial port and at 24 and 48 h post-infusion. Gamma – camera was calibrated in order to estimate source organ activity considering count rate, patient’s body diameter and source organ size. The results showed that the tumour absorbed dose ranged from 2.5 to 18.4 mGy/MBq, depending on the lesion size. Patient specific dosimetry calculations helps the physician to optimize the planning of the treatment, avoid side effects to healthy tissue and assign administered dose to treatment results.

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