昂丹西琼注射液的研制。

R E Leak, J D Woodford
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引用次数: 0

摘要

昂丹司琼注射液是一种以昂丹司琼碱为二水合盐酸的水溶液。选择注射液的pH值以达到良好的物理和化学稳定性。30℃以下避光保存,保质期3年。昂丹司琼注射液可通过缓慢静脉注射或输注稀释给药,并与几种静脉输注液体相容。此外,特定浓度的顺铂、5-氟尿嘧啶、卡铂、依托泊苷、头孢他啶、环磷酰胺和阿霉素在通过输注昂丹司琼的输注装置给药时是相容的。
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Pharmaceutical development of ondansetron injection.

Ondansetron injection is an aqueous solution containing ondansetron base as the hydrochloride dihydrate. The pH of the injection was selected to achieve good physical and chemical stability. The shelf life is 3 years when stored below 30 degrees C, protected from light. Ondansetron injection may be diluted for administration by slow intravenous injection or infusion and is compatible with several intravenous infusion fluids. In addition, specific concentrations of cisplatin, 5-fluorouracil, carboplatin, etoposide, ceftazidime, cyclophosphamide and doxorubicin are compatible when administered via a giving set delivering ondansetron by infusion.

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Effect of soybean feeding on experimental carcinogenesis--III. Carcinogenecity of nitrite and dibutylamine in mice: a histopathological study. Abstracts from the second annual meeting of the Danish Society for Cancer Research. 14 April 1989. International Conference on Supportive Care in Oncology. Brussels (Belgium), 23-25 August 1988. Proceedings. Proceedings of the Ondansetron Symposium. London, 30 June 1989. Pharmacological and anti-emetic properties of ondansetron.
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