昂丹西琼血药浓度测定及药动学。

P V Colthup, J L Palmer
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引用次数: 0

摘要

高效液相色谱法是测定血浆中昂丹司琼含量的一种准确方法。在单次分析中,以及在分析之间,从加标样品分析中获得的理论平均值和观察平均值之间的差异很小,并且获得了良好的精度。该方法已用于从药代动力学研究对象中检测数千个样品。在单次和多次口服给药和静脉输注后,建立了昂丹司琼的药代动力学特征。
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The determination in plasma and pharmacokinetics of ondansetron.

High performance liquid chromatography has been found to be an accurate method for determination of ondansetron in plasma. Within a single assay, and between assays, the differences between theoretical and observed means obtained from analysis of spiked samples were low and good precision was obtained. The method has been used to assay several thousand samples from subjects included in pharmacokinetic studies. The pharmacokinetic profile of ondansetron has been established following single and multiple oral dosing and intravenous infusions.

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Effect of soybean feeding on experimental carcinogenesis--III. Carcinogenecity of nitrite and dibutylamine in mice: a histopathological study. Abstracts from the second annual meeting of the Danish Society for Cancer Research. 14 April 1989. International Conference on Supportive Care in Oncology. Brussels (Belgium), 23-25 August 1988. Proceedings. Proceedings of the Ondansetron Symposium. London, 30 June 1989. Pharmacological and anti-emetic properties of ondansetron.
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