丘脑底核深部脑刺激对帕金森病患者焦虑和抑郁的治疗效果

IF 3.4 4区医学 Q2 CLINICAL NEUROLOGY Journal of Neurorestoratology Pub Date : 2022-03-05 DOI:10.26599/JNR.2022.9040004

Zhang Feng , Wang Feng , Li Cong-Hui , Wang Ji-Wei , Han Chun-Lei , Fan Shi-Ying , Jing Shan-Quan , Jin Hong-Bo , Du Lei , Liu Wei , Wang Zi-Feng , Yin Ze-Yu , Gao Dong-Mei , Xing Yu-Jing , Yang Chen , Zhang Jian-Guo , Meng Fan-Gang

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引用次数: 0

摘要

目的:研究丘脑底核深部脑刺激(STN-DBS)对帕金森病(PD)患者焦虑和抑郁的影响。方法:回顾性分析2018年3月至12月间行双侧STN-DBS的57例PD患者的临床资料。对患者统一帕金森病评定量表第三部分(UPDRS-Ⅲ)、汉密尔顿焦虑评定量表(HAM-A)、汉密尔顿抑郁评定量表(HAM-D)和帕金森病问卷(PDQ-39)进行评分。结果:术前及随访1、3、6个月时对患者进行评估。在6个月的随访中，HAM-A和HAM-D评分的平均改善率分别为41.7%[四分位数间距(IQR) 34.9%]和37.5% (IQR 33.4%) (p <0.001)。HAM-A评分的改善率与PDQ-39评分的改善率之间存在正相关(r = 0.538, p <0.001)，以及6个月随访时HAM-D评分的改善率与PDQ-39评分的改善率之间的差异(r = 0.404, p = 0.002)。HAM-A、HAM-D评分与帕金森病分期呈正相关(r = 0.296, p = 0.025;r = 0.380, p = 0.004)。结论:双侧STN-DBS可改善PD患者的焦虑和抑郁症状。

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Therapeutic effects of subthalamic nucleus deep brain stimulation on anxiety and depression in Parkinson's disease patients

Objective:

This study aimed to determine the effects of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety and depression in Parkinson's disease (PD) patients.

Methods:

The clinical data of 57 patients with PD who underwent bilateral STN-DBS between March and December 2018, were retrospectively analyzed. Patient scores on the Unified Parkinson's Disease Rating Scale-Part III (UPDRS-Ⅲ), the Hamilton Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), and the Parkinson's Disease Questionnaire (PDQ-39) were evaluated.

Results:

Patient evaluations took place preoperatively and at 1, 3, and 6-month follow-ups. The average patient improvement rates for HAM-A and HAM-D scores at the 6-month follow-up were 41.7% [interquartile range (IQR) 34.9%] and 37.5% (IQR 33.4%), respectively (both p < 0.001). There were positive correlations between both the rate of improvement in HAM-A scores and the rate of improvement in PDQ-39 scores (r = 0.538, p < 0.001), and between the rate of improvement in HAM-D scores and the rate of improvement in PDQ-39 scores (r = 0.404, p = 0.002) at the 6-month follow-up. HAM-A and HAM-D scores were positively correlated with the Parkinson's Hoehn-Yahr disease stage (r = 0.296, p = 0.025; and r = 0.380, p = 0.004, respectively).