西班牙医院药学和治疗委员会药物评估的活性和结果的可变性

F. Puigventós Latorre , B. Santos-Ramos , A. Ortega Eslava , M.E. Durán-García , on behalf of the Grupo de Evaluación de Novedades, Estandarización e Investigación en Selección de Medicamentos (GENESIS) de la Sociedad Española de Farmacia Hospitalaria (SEFH)
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引用次数: 4

摘要

目的量化西班牙药学和治疗委员会(P&TC)在评估和选择药物方面的活动,并描述决定纳入药物的可变性。方法采用描述性横断面调查问卷,对513家床位超过75张的医院进行调查。我们纳入了有关P&TC决议、治疗定位和评估报告的问题。招募工作于2007年11月至2008年1月期间进行。P&TC结论的可变性分为五个类别或巧合水平。结果共有175家医院参与调查,回复率为34%(占床位的54%)。每家医院评估的平均药物指征数为10.35个(7.45个)。结论为药物纳入或排斥的比例分别为75.3%和21.4%。16.2%达到治疗等效。其中64%建立了使用条件,33%纳入临床指南。关于变异性,81.0%的评估与纳入或拒绝该药物的结论一致。19.0%的人做出了自相矛盾的决定。结论医院对药物的评价和选择相当重要。不同类型医院的药品获批比例相似。在决定是否纳入研究方面存在广泛的差异,这与在其他国家进行的研究类似。他们指出,建议采用一种标准化方法。
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Variability in Activity and Results From Drug Assessments by Pharmacy and Therapeutics Committees in Spanish Hospitals

Objective

To quantify the Spanish Pharmacy and Therapeutics Commission (P&TC) activity with regard to assessing and selecting drugs and describing variability in decisions made to include them.

Method

Descriptive, cross-sectional study based on a questionnaire aimed at 513 hospitals with more than 75 beds. We included questions referring to the P&TC resolutions, the therapeutic positioning and assessment reports. Recruitment was carried out between November 2007 and January 2008. Variability among P&TC conclusions was presented in five categories or levels of coincidence.

Results

One hundred and seventy-five hospitals participated, with a response rate of 34% (54% of beds). The mean number of drug-indications assessed per hospital was 10.35 (7.45). The proportion of assessments that conclude with drug inclusion or rejection was 75.3% and 21.4%, respectively. 16.2% concluded with therapeutic equivalence. Conditions for use were established for 64% of them, and 33% were included in a clinical guide. With regard to variability, 81.0% of assessments coincided with the conclusion to include or reject the drug. A contradictory decision was made for 19.0%.

Conclusions

Drug assessment and selection in hospitals are considerable. The proportion of drugs approved is similar in different types of hospitals. There is extensive variability as regards deciding upon inclusion and is similar to studies conducted in other countries. They indicate that a standardising methodology would be recommendable.

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