vaspin rs2236242和Val109Asp omentin基因多态性及其血清水平与乳腺癌风险增加的关系

IF 0.8 Q4 GENETICS & HEREDITY Meta Gene Pub Date : 2022-02-01 DOI:10.1016/j.mgene.2022.101016
Dalia M. Asal , Noha M. Mesbah , Dina M. Abo-Elmatty , Hamada Fathy , Asmaa R. Abdel-Hamed
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引用次数: 0

摘要

乳腺癌是全球妇女癌症相关死亡的主要原因。肥胖是乳腺癌的危险因素之一,尤其是绝经后妇女。脂肪病导致肥胖,从而促进代谢失调、缺氧、炎症、胰岛素抵抗和脂肪因子如血管素和网膜蛋白-1的产生改变。本研究旨在探讨vaspin rs2236242和Val109Asp omentin基因多态性及其血清水平与绝经后女性乳腺癌发生的关系。vaspin rs2236242和Val109Asp omentin基因多态性分别采用T-ARMS-PCR和PCR-RFLP进行鉴定。葡萄糖稳态特性、脂质谱、总抗氧化能力、循环血管蛋白和网膜蛋白-1水平均被评估。vaspin rs2236242的AT基因型和Val109Asp omentin的Val/Asp基因型在乳腺癌患者中分别比TT和Asp/Asp基因型更为突出。乳腺癌患者血清vaspin和omentin-1水平明显降低。vaspin rs2236242多态性的AT基因型、omentin-1基因的杂合Asp/Val基因型以及血清vaspin和omentin-1低水平与乳腺癌发病率的关系更大。另一方面,较高水平的血清vaspin和omentin似乎可以预防乳腺癌的发生。
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Association of vaspin rs2236242 and Val109Asp omentin genes polymorphism and their serum levels with increased risk of breast cancer

Breast cancer represents the leading cause of cancer-related death in women globally. Obesity is one of the risk factors for breast cancer, particularly in postmenopausal women. Adiposopathy causes hypertrophy, which promotes metabolic dysregulation, hypoxia, inflammation, insulin resistance, and altered adipokine production such as vaspin and omentin-1. The objective of this study is to inspect the link between the vaspin rs2236242 and the Val109Asp omentin gene polymorphisms and their serum levels with breast cancer occurrence in postmenopausal females. The gene polymorphisms of vaspin rs2236242 and Val109Asp omentin were identified by T-ARMS-PCR and PCR-RFLP respectively. The glucose homeostasis traits, lipid profile, total antioxidant capacity, and circulating vaspin and omentin-1 levels were all assessed. The AT genotype of vaspin rs2236242 and the Val/Asp genotype of Val109Asp omentin were more prominent in breast cancer patients than the TT and Asp/Asp genotypes respectively. Breast cancer patients showed significant lower levels of serum vaspin and omentin-1. The AT genotype of the vaspin rs2236242 polymorphism, the heterozygous Asp/Val genotype of the omentin-1 gene, and low serum vaspin and omentin-1 levels are more associated with breast cancer incidence. On the flip side, higher levels of serum vaspin and omentin appear to protect against the incidence of breast cancer.

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来源期刊
Meta Gene
Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍: Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.
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