惊恐障碍的药物治疗——对照临床试验的重要回顾。

Psychiatric developments Pub Date : 1989-01-01
M Balestrieri, M Ruggeri, C Bellantuono
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引用次数: 0

摘要

药物治疗恐慌症的临床疗效已经在几项研究中进行了评估,特别是在过去的十年中。本文回顾了抗抑郁药和苯二氮卓类药物治疗恐慌症的双盲对照临床试验。三环抗抑郁药(主要是丙咪嗪)和苯二氮卓类药物在减少恐慌症状方面同样有效。这一证据不支持恐慌相关症状是一种精神病理实体,需要特定的抗抑郁药物治疗的假设。心理治疗与药物治疗相结合的效果更好。另一方面,MAOI的疗效仍有待证实。对苯二氮卓类药物更好的依从性可能有利于临床使用这些药物而不是抗抑郁药。然而,需要更多的前瞻性对照研究,包括随访检查,以评估这些治疗在长期治疗后的风险/收益比。
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Drug treatment of panic disorder--a critical review of controlled clinical trials.

The clinical efficacy of drug treatment for panic disorder has been evaluated in several studies, especially in the last decade. In this paper we reviewed double-blind controlled clinical trials of antidepressants and benzodiazepines in the treatment of panic disorder. Tricyclic antidepressants (principally imipramine) and benzodiazepines were equally effective in reducing panic symptomatology. This evidence does not support the hypothesis that panic-related symptomatology is a psychopathological entity, requiring a specific antidepressant drug treatment. The combination of psychological therapy with drug treatment was associated with even better outcome. On the other hand, the efficacy of MAOI remains to be demonstrated. Better compliance with benzodiazepines may favor the clinical use of these drugs rather than antidepressants. However, more prospective controlled studies including follow-up examinations are required, in order to assess the risk/benefit ratio of these treatments after long-term therapy.

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