从经典遗传标记推断的奄美岛民的遗传谱系

IF 0.8 Q4 GENETICS & HEREDITY Meta Gene Pub Date : 2021-12-01 DOI:10.1016/j.mgene.2021.100956
Yuri Nishikawa, Takafumi Ishida
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引用次数: 0

摘要

近年来,日本本土和冲绳人的基因结构逐渐被揭开。然而,由于缺乏基因数据,先前针对奄美群岛(位于日本本土和冲绳之间)居民的人类学研究提供的信息较少。在这项研究中,我们收集了两个奄美岛,奄美大岛和Kikai岛的104名受试者的dna。我们分析了mtDNA的d环区、4个y - str和4个常染色体非同义snp,以澄清奄美岛民与冲绳、日本大陆和东亚其他地区人群的遗传结构。我们发现奄美岛民在mtDNA和Y-STR上表现出介于日本大陆和冲绳之间的遗传中间位置。然而,奄美岛民的几个常染色体snp的频率表明,奄美岛民与日本大陆人存在显著差异,这可能是来自冲绳的基因流,而不是自然选择。此外,几个等位基因的极高或极低频率暗示了Kikai岛民的奠基人效应。请注意,由于本研究的样本量和等位基因数量小,因此结果有解释的余地。地理上广泛而详细的采样和全基因组分析正在等待中。
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Genetic lineage of the Amami islanders inferred from classical genetic markers

The genetic structure of the people of mainland Japan and Okinawa has been gradually unveiled in recent years. However, previous anthropological studies dealing with people in the Amami islands, located between mainland Japan and Okinawa, were less informative because of the lack of genetic data. In this study, we collected DNAs from 104 subjects in two of the Amami islands, Amami-Oshima island and Kikai island. We analyzed the D-loop region of mtDNA, four Y-STRs, and four autosomal nonsynonymous SNPs to clarify the Amami islanders' genetic structure compared with peoples in Okinawa, mainland Japan, and other regions of East Asia. We found that the Amami islanders showed a genetically intermediate position between mainland Japan and Okinawa in mtDNA and Y-STR. However, the frequencies of several autosomal SNPs in the Amami islanders indicated a significant difference from mainland Japanese, which may be because of the gene flow from Okinawa but not natural selection. Moreover, extremely high or low frequencies of several alleles implied a founder effect in Kikai islanders. Note that there is room for the interpretation of the results because of the small sample size and number of alleles in the present study. Geographically broad and detailed samplings and genome-wide analyses are awaited.

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来源期刊
Meta Gene
Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍: Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.
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