在日本精神分裂症患者中,较慢的氯氮平滴定与氯氮平诱发的发烧延迟发作有关。

IF 3 Q2 PSYCHIATRY Schizophrenia (Heidelberg, Germany) Pub Date : 2023-11-20 DOI:10.1038/s41537-023-00412-6
Yuki Kikuchi, Yuji Yada, Yuji Otsuka, Fumiaki Ito, Hiroaki Tanifuji, Hiroshi Komatsu, Hiroaki Tomita
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摘要

氯氮平引起的发热标志着其炎症和潜在危及生命的不良反应的开始,如心肌炎。我们回顾性分析了254名日本患者氯氮平滴定率与发热发病日期的相关性,其中包括55名出现氯氮平诱发发热的难治性精神分裂症患者。皮尔逊积差相关性表明,随着滴定速度的减慢,发烧发病日期明显延迟。大多数发热病例发生在4周内,即使滴定缓慢。因此,临床医生应保持警惕,在氯氮平开始使用后4周内监测氯氮平引起的发热,无论滴定率如何。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Slower clozapine titration is associated with delayed onset of clozapine-induced fever among Japanese patients with schizophrenia.

Clozapine-induced fever marks the beginning of its inflammatory and potentially life-threatening adverse effects, such as myocarditis. We retrospectively analyzed the correlation between clozapine titration rate and fever onset date in 254 Japanese patients, including 55 with treatment-resistant schizophrenia who developed clozapine-induced fever. Pearson's product-moment correlation indicated a significant delay in the fever onset date with slower titration. Most fever onset cases occurred within 4 weeks, even with slow titration. Therefore, clinicians should remain vigilant in monitoring clozapine-induced fever within 4 weeks of clozapine initiation, regardless of the titration rate.

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