终末期肾病患者的免疫功能障碍免疫衰老-综述。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2024-03-23 Print Date: 2024-03-01 DOI:10.2478/rjim-2023-0030
Viorica Ileana Bumbea, Horia Bumbea, Ana Maria Vladareanu
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引用次数: 0

摘要

机体对环境因素的防御是通过先天免疫系统和适应性免疫系统的物理屏障和细胞来实现的。终末期肾病(ESKD)患者,特别是那些接受血液透析治疗的患者,在功能和不同白细胞亚群的数量或百分比上都有变化。在单核细胞和淋巴细胞亚群水平上描述了变化,这些变化与免疫缺陷和与退行性变化和心血管风险增加相关的促炎状态有关。在过去的几年里,这些异常与衰老导致的变化进行了比较。此外,在ESKD患者中观察到的与慢性炎症有关的免疫衰老的相似之处被描述为所谓的“炎症综合征”。
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Immune dysfunction in patients with end stage kidney disease; Immunosenescence - Review.

The body's defense against environmental factors is realized by physical barriers and cells of both the innate and adaptive immune systems. Patients with end stage kidney disease (ESKD), especially those treated by hemodialysis, have changes in both the function and the number or percent of different leukocyte subsets. Changes were described at the level of monocytes and lymphocyte subsets, which are associated with immunodeficiencies and pro-inflammatory status correlated with degenerative changes and increased cardiovascular risk. These abnormalities have been compared over the past years with alterations appearing as a result ageing. Also, similitudes regarding immunosenescence observed in ESKD patients, in combination with chronic inflammation, are described as the so-called "inflammaging syndrome".

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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