pars肝纤维化队列研究:一项关于患病率及相关因素的大规模研究。

IF 1.1 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Arab Journal of Gastroenterology Pub Date : 2023-11-01 DOI:10.1016/j.ajg.2023.10.001
Amin Nakhostin-Ansari , Seyed Hossein Hosseini-Asl , Fatemeh Aliasgharpour , Mohammad Ahmadi , Abdollah Gandomkar , Fatemeh Malekzadeh , Hossein Poustchi , Mohammad Reza Fattahi , Amir Anushiravani , Reza Malekzadeh
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引用次数: 0

摘要

背景和研究目的:纤维化-4 (FIB-4)是一种非侵入性评分系统,用于评估肝纤维化严重程度,作为慢性肝病的生物标志物。我们的目的是使用FIB-4在社区水平上估计慢性肝病的患病率和严重程度。患者和方法:本横断面研究使用收集自伊朗法尔斯省Valashar的Pars队列数据库进行。参与者根据FIB-4评分分为三组:低风险肝纤维化(FIB 3.25)。结果:共纳入9269例患者,平均年龄52.65岁,其中男性4278例(46.2%)。在所有参与者中,7853人(84.7%)属于低风险组,65人(0.7%)属于高风险组。在最后的有序回归模型中,男性、农民或牧场主、居住在农村、阿片类药物使用史、黄疸史、无糖尿病史、抑郁史和HBs Ag阳性与FIB-4得分较高独立相关。结论:我们的研究表明,男性、居住在农村地区的个人以及从事农业和牧场职业的人面临着更高的肝纤维化风险。这些发现强调了对这些高危人群进行肝纤维化早期检测和有效管理的未来规划的必要性。
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Liver fibrosis in pars cohort study: A large-scale study on the prevalence and correlated factors

Backgrounds and study aims

The fibrosis-4 (FIB-4) is a non-invasive scoring system for estimating liver fibrosis severity as a biomarker of chronic liver disease. We aimed to estimate the prevalence and severity of chronic liver disease at the community level using FIB-4.

Patients and methods

This cross-sectional study was conducted using the Pars Cohort database collected in Valashar, Fars province, Iran. Participants were divided into three groups based on their FIB-4 scores: low risk of liver fibrosis (FIB < 1.45), intermediate cases (1.45 ≤ FIB-4 ≤ 3.25), and high risk of liver fibrosis (FIB-4 > 3.25).

Results

In total, 9269 individuals with a mean age of 52.65 years were enrolled in the study, of which 4278 (46.2 %) were male. Among all participants, 7853 (84.7 %) were in the low-risk, and 65 (0.7 %) were in the high-risk groups. In the final ordinal regression model, male gender, being a farmer or rancher, living in rural areas, history of opioid use, history of jaundice, no history of diabetes, history of depression, and positive HBs Ag were independently associated with higher FIB-4 scores.

Conclusion

Our study revealed that males, individuals residing in rural areas, and those engaged in farming and ranching occupations face a heightened risk of liver fibrosis. These findings emphasize the need for future programs for early detection and effective management of liver fibrosis in these at-risk populations.

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来源期刊
Arab Journal of Gastroenterology
Arab Journal of Gastroenterology Medicine-Gastroenterology
CiteScore
2.70
自引率
0.00%
发文量
52
期刊介绍: Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.
期刊最新文献
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