Arnaud Dieudonné, Stéphanie Becker, Miguel Soares, Claire Hollenbeck, Marie-Christine De Goltstein, Pierre Vera, Robin Santus
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The histologic analysis showed that the Lipiodol® ultra-fluid distributes homogeneously in the tumor up to 12 days after injection. The X-ray μCT images showed that Lipiodol® ultra-fluid has a more distal penetration in the tumor than microspheres. The entropy (disorder of the system) in the L group was significantly higher than in the M group (4.06 vs 2.67, p = 0.01). Equivalent uniform biological effective doses (EUBED) for a tumor-absorbed dose of 100 Gy were greater in the L group but without statistical significance except for <sup>177</sup>Lu (p = 0.03). The radionuclides ranking by EUBED (from high to low) was <sup>90</sup>Y, <sup>188</sup>Re, <sup>32</sup>P, <sup>166</sup>Ho, <sup>131</sup>I, and <sup>177</sup>Lu.</p><p><strong>Conclusions: </strong>This study showed a higher ability of Lipiodol® ultra-fluid to penetrate the tumor that translated into a higher EUBED. 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引用次数: 0
摘要
背景:放射栓塞是治疗局部早期肝细胞癌的一种治疗选择。本研究的目的是评估Lipiodol®超流体和微球在30只新西兰兔肝脏VX2肿瘤移植中的分布,并模拟不同β -发射体(90Y、188Re、32P、166Ho、131I和177Lu)对其效果的影响。结果:30只兔中有23只兔有可利用的数据:脂醇®超液组14只(L组),微球组6只(M组),对照组3只(C组)。组织学分析显示,注射后12天内,脂醇®超液在肿瘤内分布均匀。x射线μCT图像显示,Lipiodol®超流体在肿瘤中具有比微球更远端的穿透性。L组的熵(系统无序度)显著高于M组(4.06 vs 2.67, p = 0.01)。肿瘤吸收剂量为100 Gy时,L组等效均匀生物有效剂量(EUBED)较大,但除177Lu外,无统计学意义(p = 0.03)。EUBED的放射性核素从高到低依次为90Y、188Re、32P、166Ho、131I和177Lu。结论:本研究表明,Lipiodol®超流体穿透肿瘤的能力更高,转化为更高的EUBED。虽然32P、166Ho和188Re可以达到类似的结果,但本研究证实90Y是放射栓塞的良好候选者。
Biological efficacy of simulated radiolabeled Lipiodol® ultra-fluid and microspheres for various beta emitters: study based on VX2 tumors.
Background: Radioembolization is one therapeutic option for the treatment of locally early-stage hepatocellular carcinoma. The aim of this study was to evaluate the distribution of Lipiodol® ultra-fluid and microspheres and to simulate their effectiveness with different beta emitters (90Y, 188Re, 32P, 166Ho, 131I, and 177Lu) on VX2 tumors implanted in the liver of 30 New Zealand rabbits.
Results: Twenty-three out of 30 rabbits had exploitable data: 14 in the group that received Lipiodol® ultra-fluid (group L), 6 in the group that received microspheres (group M), and 3 in the control group (group C). The histologic analysis showed that the Lipiodol® ultra-fluid distributes homogeneously in the tumor up to 12 days after injection. The X-ray μCT images showed that Lipiodol® ultra-fluid has a more distal penetration in the tumor than microspheres. The entropy (disorder of the system) in the L group was significantly higher than in the M group (4.06 vs 2.67, p = 0.01). Equivalent uniform biological effective doses (EUBED) for a tumor-absorbed dose of 100 Gy were greater in the L group but without statistical significance except for 177Lu (p = 0.03). The radionuclides ranking by EUBED (from high to low) was 90Y, 188Re, 32P, 166Ho, 131I, and 177Lu.
Conclusions: This study showed a higher ability of Lipiodol® ultra-fluid to penetrate the tumor that translated into a higher EUBED. This study confirms 90Y as a good candidate for radioembolization, although 32P, 166Ho, and 188Re can achieve similar results.
EJNMMI ResearchRADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING&nb-
CiteScore
5.90
自引率
3.10%
发文量
72
审稿时长
13 weeks
期刊介绍:
EJNMMI Research publishes new basic, translational and clinical research in the field of nuclear medicine and molecular imaging. Regular features include original research articles, rapid communication of preliminary data on innovative research, interesting case reports, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical research or ethical aspects of research are also welcome. Timely reviews provide updates on current applications, issues in imaging research and translational aspects of nuclear medicine and molecular imaging technologies.
The main emphasis is placed on the development of targeted imaging with radiopharmaceuticals within the broader context of molecular probes to enhance understanding and characterisation of the complex biological processes underlying disease and to develop, test and guide new treatment modalities, including radionuclide therapy.