肠道菌群及其功能代谢物与妇女产前抑郁症的关系

IF 4.3 2区 医学 Q1 NEUROSCIENCES Neurobiology of Stress Pub Date : 2023-11-17 DOI:10.1016/j.ynstr.2023.100592
Tianqu Xie , Xiaoxiao Fan , Hanghang Pang , Tianzi Zang , Ni Wu , Juan Liu , Ziying Li , Sha Li , Quanfei Zhu , Julia Elise Slack , Jinbing Bai , Yu Xu , Yanqun Liu
{"title":"肠道菌群及其功能代谢物与妇女产前抑郁症的关系","authors":"Tianqu Xie ,&nbsp;Xiaoxiao Fan ,&nbsp;Hanghang Pang ,&nbsp;Tianzi Zang ,&nbsp;Ni Wu ,&nbsp;Juan Liu ,&nbsp;Ziying Li ,&nbsp;Sha Li ,&nbsp;Quanfei Zhu ,&nbsp;Julia Elise Slack ,&nbsp;Jinbing Bai ,&nbsp;Yu Xu ,&nbsp;Yanqun Liu","doi":"10.1016/j.ynstr.2023.100592","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The gut microbiota may affect mood through the microbiota-gut-brain axis. The purpose of this study was to examine the effect of the gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs), on prenatal depression and to determine the role of 5-hydroxytryptamine (5-HT) on prenatal depression in association with the gut microbiota and its metabolites (i.e. SCFAs).</p></div><div><h3>Methods</h3><p>Eighty-six pregnant women in the third trimester were recruited. Prenatal depression was determined by a score of 10 via the Edinburgh Postpartum Depression Scale. Demographic data, stool, and blood samples were collected. The gut microbiota and its metabolites SCFAs were determined by 16S rRNA gene sequencing and liquid chromatography-mass spectrometry analysis. Plasma 5-HT was determined by gas chromatography-mass spectrometry analysis.</p></div><div><h3>Results</h3><p>After controlling relevant covariates, our results found the higher the abundance of <em>Candidatus_Soleaferrea</em>, the lower the risk of prenatal depression; the higher the concentration of propanoic acid, the higher risk of prenatal depression. Our results also found the lower the plasma 5-HT, the higher the risk of prenatal depression, and 5-HT was related to <em>unclassified_c_Clostridia</em> and <em>NK4A214_group</em>. However, results of this study did not support the moderating effect of plasma 5-HT on the association of <em>Candidatus_Soleaferrea</em> or propionic acid with prenatal depression.</p></div><div><h3>Conclusions</h3><p>Results of this study supported that changes in certain gut microbiota, SCFAs, and plasma 5-HT during pregnancy were associated with prenatal depression. This finding provides new ideas for interventions based on diet or probiotics to regulate mood during pregnancy.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"28 ","pages":"Article 100592"},"PeriodicalIF":4.3000,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352289523000802/pdfft?md5=98763d2ddddb880078f3d3989f5c1218&pid=1-s2.0-S2352289523000802-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Association between gut microbiota and its functional metabolites with prenatal depression in women\",\"authors\":\"Tianqu Xie ,&nbsp;Xiaoxiao Fan ,&nbsp;Hanghang Pang ,&nbsp;Tianzi Zang ,&nbsp;Ni Wu ,&nbsp;Juan Liu ,&nbsp;Ziying Li ,&nbsp;Sha Li ,&nbsp;Quanfei Zhu ,&nbsp;Julia Elise Slack ,&nbsp;Jinbing Bai ,&nbsp;Yu Xu ,&nbsp;Yanqun Liu\",\"doi\":\"10.1016/j.ynstr.2023.100592\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The gut microbiota may affect mood through the microbiota-gut-brain axis. The purpose of this study was to examine the effect of the gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs), on prenatal depression and to determine the role of 5-hydroxytryptamine (5-HT) on prenatal depression in association with the gut microbiota and its metabolites (i.e. SCFAs).</p></div><div><h3>Methods</h3><p>Eighty-six pregnant women in the third trimester were recruited. Prenatal depression was determined by a score of 10 via the Edinburgh Postpartum Depression Scale. Demographic data, stool, and blood samples were collected. The gut microbiota and its metabolites SCFAs were determined by 16S rRNA gene sequencing and liquid chromatography-mass spectrometry analysis. Plasma 5-HT was determined by gas chromatography-mass spectrometry analysis.</p></div><div><h3>Results</h3><p>After controlling relevant covariates, our results found the higher the abundance of <em>Candidatus_Soleaferrea</em>, the lower the risk of prenatal depression; the higher the concentration of propanoic acid, the higher risk of prenatal depression. Our results also found the lower the plasma 5-HT, the higher the risk of prenatal depression, and 5-HT was related to <em>unclassified_c_Clostridia</em> and <em>NK4A214_group</em>. However, results of this study did not support the moderating effect of plasma 5-HT on the association of <em>Candidatus_Soleaferrea</em> or propionic acid with prenatal depression.</p></div><div><h3>Conclusions</h3><p>Results of this study supported that changes in certain gut microbiota, SCFAs, and plasma 5-HT during pregnancy were associated with prenatal depression. This finding provides new ideas for interventions based on diet or probiotics to regulate mood during pregnancy.</p></div>\",\"PeriodicalId\":19125,\"journal\":{\"name\":\"Neurobiology of Stress\",\"volume\":\"28 \",\"pages\":\"Article 100592\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2023-11-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2352289523000802/pdfft?md5=98763d2ddddb880078f3d3989f5c1218&pid=1-s2.0-S2352289523000802-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurobiology of Stress\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352289523000802\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurobiology of Stress","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352289523000802","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

肠道菌群可能通过菌群-肠-脑轴影响情绪。本研究的目的是研究肠道微生物群及其代谢物,如短链脂肪酸(SCFAs)对产前抑郁症的影响,并确定5-羟色胺(5-HT)在与肠道微生物群及其代谢物(即SCFAs)相关的产前抑郁症中的作用。方法选取孕晚期孕妇86例。产前抑郁是通过爱丁堡产后抑郁量表以10分来确定的。收集了人口统计资料、粪便和血液样本。采用16S rRNA基因测序和液相色谱-质谱分析方法测定肠道菌群及其代谢产物SCFAs。采用气相色谱-质谱法测定血浆5-羟色胺含量。结果在控制相关变量后发现,Candidatus_Soleaferrea丰度越高,产前抑郁风险越低;丙酸浓度越高,产前抑郁的风险越高。我们的研究结果还发现,血浆5-HT越低,产前抑郁的风险越高,5-HT与unclassified_c_Clostridia和NK4A214_group有关。然而,本研究结果不支持血浆5-羟色胺在Candidatus_Soleaferrea或丙酸与产前抑郁的关联中的调节作用。结论妊娠期某些肠道菌群、scfa和血浆5-羟色胺的变化与产前抑郁有关。这一发现为基于饮食或益生菌的干预来调节怀孕期间的情绪提供了新的思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Association between gut microbiota and its functional metabolites with prenatal depression in women

Background

The gut microbiota may affect mood through the microbiota-gut-brain axis. The purpose of this study was to examine the effect of the gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs), on prenatal depression and to determine the role of 5-hydroxytryptamine (5-HT) on prenatal depression in association with the gut microbiota and its metabolites (i.e. SCFAs).

Methods

Eighty-six pregnant women in the third trimester were recruited. Prenatal depression was determined by a score of 10 via the Edinburgh Postpartum Depression Scale. Demographic data, stool, and blood samples were collected. The gut microbiota and its metabolites SCFAs were determined by 16S rRNA gene sequencing and liquid chromatography-mass spectrometry analysis. Plasma 5-HT was determined by gas chromatography-mass spectrometry analysis.

Results

After controlling relevant covariates, our results found the higher the abundance of Candidatus_Soleaferrea, the lower the risk of prenatal depression; the higher the concentration of propanoic acid, the higher risk of prenatal depression. Our results also found the lower the plasma 5-HT, the higher the risk of prenatal depression, and 5-HT was related to unclassified_c_Clostridia and NK4A214_group. However, results of this study did not support the moderating effect of plasma 5-HT on the association of Candidatus_Soleaferrea or propionic acid with prenatal depression.

Conclusions

Results of this study supported that changes in certain gut microbiota, SCFAs, and plasma 5-HT during pregnancy were associated with prenatal depression. This finding provides new ideas for interventions based on diet or probiotics to regulate mood during pregnancy.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
期刊最新文献
Behavioral coping with chronic defeat stress in mice: A systematic review of current protocols Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress Transcriptome dynamics in mouse amygdala under acute and chronic stress revealed by thiol-labeled RNA sequencing Transient impact of chronic social stress on effort-based reward motivation in non-food restricted mice: Involvement of corticosterone Acute stress activates basolateral amygdala neurons expressing corticotropin-releasing hormone receptor type 1 (CRHR1): Topographical distribution and projection-specific activation in male and female rats
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1