{"title":"封面图:新型5-脂氧合酶抑制剂N-((6-(取代氨基)-2-甲基- 2h -铬-2-基)甲基)-N-甲基苯磺酰胺衍生物(BKCS 11/2023)的开发(英文","authors":"","doi":"10.1002/bkcs.12569","DOIUrl":null,"url":null,"abstract":"<p>The cover picture illustrates the design process of a new 5-LO inhibitor through molecular hybridization. The highlighted portions in each chemical structure represent the regions where structural fusion is applied, and the sparks depict the process of fusion. The target compound acts on the 5-LO protein in mouse, relieving the ear edema. The drugs indicated by the prohibition sign in the bottom right corner are steroid-based drug and a 5-LO target drug called Zeiluton, both have toxicity issues. More details are available in the article by Young-Chang Kim, Aizhan Abdildinova, Ye Jin Shin, Dong Kyun Han, Jong Yeon Hwang, Hyae Gyeong Cheon, Young-Dae Gong.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.12569","citationCount":"0","resultStr":"{\"title\":\"Cover Picture: Development for a new 5-lipoxygenase inhibitors of N-((6-(substituted-amino)-2-methyl-2H-chromen-2-yl)methyl)-N-methyl benzenesulfonamide derivatives (BKCS 11/2023) Young-Chang Kim, Aizhan Abdildinova, Ye Jin Shin, Dong Kyun Han, Jong Yeon Hwang, Hyae Gyeong Cheon, Young-Dae Gong\",\"authors\":\"\",\"doi\":\"10.1002/bkcs.12569\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The cover picture illustrates the design process of a new 5-LO inhibitor through molecular hybridization. The highlighted portions in each chemical structure represent the regions where structural fusion is applied, and the sparks depict the process of fusion. The target compound acts on the 5-LO protein in mouse, relieving the ear edema. The drugs indicated by the prohibition sign in the bottom right corner are steroid-based drug and a 5-LO target drug called Zeiluton, both have toxicity issues. More details are available in the article by Young-Chang Kim, Aizhan Abdildinova, Ye Jin Shin, Dong Kyun Han, Jong Yeon Hwang, Hyae Gyeong Cheon, Young-Dae Gong.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":54252,\"journal\":{\"name\":\"Bulletin of the Korean Chemical Society\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2023-11-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.12569\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of the Korean Chemical Society\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/bkcs.12569\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of the Korean Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bkcs.12569","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
封面图展示了一种新型5-LO抑制剂的分子杂交设计过程。每个化学结构中突出显示的部分代表了应用结构融合的区域，火花描述了融合的过程。目标化合物作用于小鼠5-LO蛋白，减轻耳部水肿。右下角的禁用标志显示的药物是基于类固醇的药物和一种名为Zeiluton的5-LO靶标药物，两者都有毒性问题。金永昌，Aizhan Abdildinova, Ye Jin Shin, Dong Kyun Han, Jong Yeon Hwang, Hyae Gyeong Cheon, Young-Dae Gong的文章提供了更多细节。
Cover Picture: Development for a new 5-lipoxygenase inhibitors of N-((6-(substituted-amino)-2-methyl-2H-chromen-2-yl)methyl)-N-methyl benzenesulfonamide derivatives (BKCS 11/2023) Young-Chang Kim, Aizhan Abdildinova, Ye Jin Shin, Dong Kyun Han, Jong Yeon Hwang, Hyae Gyeong Cheon, Young-Dae Gong
The cover picture illustrates the design process of a new 5-LO inhibitor through molecular hybridization. The highlighted portions in each chemical structure represent the regions where structural fusion is applied, and the sparks depict the process of fusion. The target compound acts on the 5-LO protein in mouse, relieving the ear edema. The drugs indicated by the prohibition sign in the bottom right corner are steroid-based drug and a 5-LO target drug called Zeiluton, both have toxicity issues. More details are available in the article by Young-Chang Kim, Aizhan Abdildinova, Ye Jin Shin, Dong Kyun Han, Jong Yeon Hwang, Hyae Gyeong Cheon, Young-Dae Gong.
期刊介绍：
The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.
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