伊匹单抗后小血管炎导致严重急性肾损伤:1例报告。

IF 1.5 4区医学 Q3 DERMATOLOGY Melanoma Research Pub Date : 2024-02-01 Epub Date: 2023-11-28 DOI:10.1097/CMR.0000000000000928

Rui Duarte, Filipa Trigo, Ivan Luz, Paulo Santos

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引用次数: 0

摘要

免疫检查点抑制剂是一种有效的单克隆抗体，用于癌症治疗，特别是转移性黑色素瘤。它们的目标是负责癌细胞逃避免疫系统的蛋白质。然而，它们的使用会导致免疫相关的不良事件，皮肤和胃肠道通常会受到影响。肾脏受累是罕见的，间质性肾炎是最常见的表现。在一个独特的情况下，经肾活检证实的小血管炎伴小动脉免疫沉积在伊匹单抗治疗后被观察到。

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Small-vessel vasculitis leading to severe acute kidney injury after ipilimumab: a case report.

Immune checkpoint inhibitors are effective monoclonal antibodies used in cancer treatment, particularly in metastatic melanoma. They target proteins responsible for cancer cells evading the immune system. However, their use can lead to immune-related adverse events, with the skin and gastrointestinal tract being commonly affected. Kidney involvement is rarer, with interstitial nephritis being the most common manifestation. In a unique case, kidney biopsy-proven small-vessel vasculitis with arteriolar immune deposition was observed following ipilimumab administration.

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来源期刊

Melanoma Research 医学-皮肤病学

CiteScore

3.40

自引率

4.50%

发文量

139

审稿时长

6-12 weeks

期刊介绍： Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.