{"title":"2型糖尿病前期大鼠全身振动对骨质退化的预防作用","authors":"Akira Minematsu, Yasue Nishii","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To examine effects of whole-body vibration (WBV) on bone properties in pre-type 2 diabetes mellitus (T2DM) rats.</p><p><strong>Methods: </strong>Six-week-old male Hos:ZFDM-<i>Lepr <sup>fa</sup></i>, <i>fa/fa</i> (DM) and Hos:ZFDM-<i>Lepr<sup>fa</sup>,fa/+</i> (CON; untreated non-DM) rats were used in the experiments. Half of DM rats were subjected to WBV (45 Hz, 0.5 g, 15 min/day, 5 days/week) for 8 weeks (WBV group), and the other half was not (DM group).</p><p><strong>Results: </strong>Bone mass, trabecular bone microstructure (TBMS), and cortical bone geometry (CBG) parameters were worse in the DM and WBV groups compared with the CON group. Maximum load was significantly decreased in the DM group compared with the CON group, and the break point was significantly higher in the WBV group compared with the DM group. Serum levels of bone specific alkaline phosphatase were significantly lower in the WBV group compared with the CON group. Glycemic control was not worse in the WBV group compared with the DM group, but not the same levels as the CON group.</p><p><strong>Conclusions: </strong>These findings suggest that WBV can potentially delay the decrease in maximum load, although it does not prevent the deterioration of bone mass, TBMS, and CBG parameters.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"23 4","pages":"426-435"},"PeriodicalIF":1.7000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696377/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prevention of bone deterioration by whole-body vibration in a rat model of pre-type 2 diabetes.\",\"authors\":\"Akira Minematsu, Yasue Nishii\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To examine effects of whole-body vibration (WBV) on bone properties in pre-type 2 diabetes mellitus (T2DM) rats.</p><p><strong>Methods: </strong>Six-week-old male Hos:ZFDM-<i>Lepr <sup>fa</sup></i>, <i>fa/fa</i> (DM) and Hos:ZFDM-<i>Lepr<sup>fa</sup>,fa/+</i> (CON; untreated non-DM) rats were used in the experiments. Half of DM rats were subjected to WBV (45 Hz, 0.5 g, 15 min/day, 5 days/week) for 8 weeks (WBV group), and the other half was not (DM group).</p><p><strong>Results: </strong>Bone mass, trabecular bone microstructure (TBMS), and cortical bone geometry (CBG) parameters were worse in the DM and WBV groups compared with the CON group. Maximum load was significantly decreased in the DM group compared with the CON group, and the break point was significantly higher in the WBV group compared with the DM group. Serum levels of bone specific alkaline phosphatase were significantly lower in the WBV group compared with the CON group. Glycemic control was not worse in the WBV group compared with the DM group, but not the same levels as the CON group.</p><p><strong>Conclusions: </strong>These findings suggest that WBV can potentially delay the decrease in maximum load, although it does not prevent the deterioration of bone mass, TBMS, and CBG parameters.</p>\",\"PeriodicalId\":16430,\"journal\":{\"name\":\"Journal of musculoskeletal & neuronal interactions\",\"volume\":\"23 4\",\"pages\":\"426-435\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696377/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of musculoskeletal & neuronal interactions\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of musculoskeletal & neuronal interactions","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
目的:探讨全身振动(WBV)对2型糖尿病(T2DM)前期大鼠骨特性的影响。方法:6周龄雄性Hos:ZFDM-Leprfa,fa/ fa (DM); Hos:ZFDM-Leprfa,fa/+ (CON);实验采用未经治疗的非糖尿病大鼠。一半DM大鼠连续8周(45 Hz, 0.5 g, 15 min/天，5天/周)(WBV组)，另一半不(DM组)。结果:DM组和WBV组骨量、骨小梁微结构(TBMS)和皮质骨几何参数(CBG)均较CON组差。DM组的最大负荷较CON组显著降低，WBV组的断裂点较DM组显著升高。与CON组相比，WBV组血清骨特异性碱性磷酸酶水平显著降低。与DM组相比，WBV组的血糖控制并不差，但与CON组的水平不同。结论:这些发现表明，尽管WBV不能阻止骨量、TBMS和CBG参数的恶化，但它可以潜在地延缓最大负荷的下降。
Prevention of bone deterioration by whole-body vibration in a rat model of pre-type 2 diabetes.
Objectives: To examine effects of whole-body vibration (WBV) on bone properties in pre-type 2 diabetes mellitus (T2DM) rats.
Methods: Six-week-old male Hos:ZFDM-Lepr fa, fa/fa (DM) and Hos:ZFDM-Leprfa,fa/+ (CON; untreated non-DM) rats were used in the experiments. Half of DM rats were subjected to WBV (45 Hz, 0.5 g, 15 min/day, 5 days/week) for 8 weeks (WBV group), and the other half was not (DM group).
Results: Bone mass, trabecular bone microstructure (TBMS), and cortical bone geometry (CBG) parameters were worse in the DM and WBV groups compared with the CON group. Maximum load was significantly decreased in the DM group compared with the CON group, and the break point was significantly higher in the WBV group compared with the DM group. Serum levels of bone specific alkaline phosphatase were significantly lower in the WBV group compared with the CON group. Glycemic control was not worse in the WBV group compared with the DM group, but not the same levels as the CON group.
Conclusions: These findings suggest that WBV can potentially delay the decrease in maximum load, although it does not prevent the deterioration of bone mass, TBMS, and CBG parameters.
期刊介绍：
The Journal of Musculoskeletal and Neuronal Interactions (JMNI) is an academic journal dealing with the pathophysiology and treatment of musculoskeletal disorders. It is published quarterly (months of issue March, June, September, December). Its purpose is to publish original, peer-reviewed papers of research and clinical experience in all areas of the musculoskeletal system and its interactions with the nervous system, especially metabolic bone diseases, with particular emphasis on osteoporosis. Additionally, JMNI publishes the Abstracts from the biannual meetings of the International Society of Musculoskeletal and Neuronal Interactions, and hosts Abstracts of other meetings on topics related to the aims and scope of JMNI.
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