{"title":"1.8%硫化硒与2%酮康唑洗发水治疗花斑糠疹的真菌学疗效和安全性:一项双盲随机对照试验。","authors":"Lusiana, Lis Surachmiati, Siti Rizny Fitriana Saldi, Trah Lusianingtyas, Kusmarinah Bramono","doi":"10.18683/germs.2022.1351","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Although it has long been used as a topical treatment of pityriasis versicolor (PV), the efficacy of topical selenium disulfide as compared to topical ketoconazole in the treatment of PV remains unclear. This study aims to assess the mycological efficacy and safety of SeS<sub>2</sub> 1.8% shampoo and ketoconazole 2% shampoo for the treatment of PV.</p><p><strong>Methods: </strong>A double-blind randomized controlled trial was performed in patients with PV during September-December 2018, based on block randomization. Physical examinations, scale provocation test, Wood's lamp, and potassium hydroxide examination were conducted. Intention to treat analysis was performed to evaluate the mycological efficacy.</p><p><strong>Results: </strong>The mycological efficacy and side effect were not significantly different between the ketoconazole group and the selenium group; 94% vs 86% (RR=2.3(95%CI 0.6-8.5), p=0.182), and 22% versus 8%.</p><p><strong>Conclusions: </strong>SeS2 1.8% has the same mycological efficacy and side effect as compared to ketoconazole 2% in the treatment of PV.</p>","PeriodicalId":45107,"journal":{"name":"GERMS","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660221/pdf/","citationCount":"0","resultStr":"{\"title\":\"The mycological efficacy and safety of selenium sulfide 1.8% versus ketoconazole 2% shampoo in pityriasis versicolor: A double-blind randomized controlled trial.\",\"authors\":\"Lusiana, Lis Surachmiati, Siti Rizny Fitriana Saldi, Trah Lusianingtyas, Kusmarinah Bramono\",\"doi\":\"10.18683/germs.2022.1351\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Although it has long been used as a topical treatment of pityriasis versicolor (PV), the efficacy of topical selenium disulfide as compared to topical ketoconazole in the treatment of PV remains unclear. This study aims to assess the mycological efficacy and safety of SeS<sub>2</sub> 1.8% shampoo and ketoconazole 2% shampoo for the treatment of PV.</p><p><strong>Methods: </strong>A double-blind randomized controlled trial was performed in patients with PV during September-December 2018, based on block randomization. Physical examinations, scale provocation test, Wood's lamp, and potassium hydroxide examination were conducted. Intention to treat analysis was performed to evaluate the mycological efficacy.</p><p><strong>Results: </strong>The mycological efficacy and side effect were not significantly different between the ketoconazole group and the selenium group; 94% vs 86% (RR=2.3(95%CI 0.6-8.5), p=0.182), and 22% versus 8%.</p><p><strong>Conclusions: </strong>SeS2 1.8% has the same mycological efficacy and side effect as compared to ketoconazole 2% in the treatment of PV.</p>\",\"PeriodicalId\":45107,\"journal\":{\"name\":\"GERMS\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2022-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660221/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"GERMS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18683/germs.2022.1351\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/12/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"GERMS","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18683/germs.2022.1351","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/12/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
摘要
简介:虽然它长期以来被用作局部治疗花斑糠疹(PV)，但与外用酮康唑相比，外用二硫化硒治疗PV的疗效尚不清楚。本研究旨在评价SeS2 1.8%洗发水和酮康唑2%洗发水治疗PV的真菌学疗效和安全性。方法:2018年9 - 12月，采用分组随机法，对PV患者进行双盲随机对照试验。进行体格检查、水垢激发试验、伍德灯、氢氧化钾检查。进行意向治疗分析，评价真菌学疗效。结果:酮康唑组与硒组的真菌学疗效和毒副作用无显著差异;94% vs 86% (RR = 2.3 (95% ci 0.6 - -8.5), p = 0.182),和分别为22%和8%。结论:SeS2 1.8%与酮康唑2%治疗PV具有相同的真菌学疗效和毒副作用。
The mycological efficacy and safety of selenium sulfide 1.8% versus ketoconazole 2% shampoo in pityriasis versicolor: A double-blind randomized controlled trial.
Introduction: Although it has long been used as a topical treatment of pityriasis versicolor (PV), the efficacy of topical selenium disulfide as compared to topical ketoconazole in the treatment of PV remains unclear. This study aims to assess the mycological efficacy and safety of SeS2 1.8% shampoo and ketoconazole 2% shampoo for the treatment of PV.
Methods: A double-blind randomized controlled trial was performed in patients with PV during September-December 2018, based on block randomization. Physical examinations, scale provocation test, Wood's lamp, and potassium hydroxide examination were conducted. Intention to treat analysis was performed to evaluate the mycological efficacy.
Results: The mycological efficacy and side effect were not significantly different between the ketoconazole group and the selenium group; 94% vs 86% (RR=2.3(95%CI 0.6-8.5), p=0.182), and 22% versus 8%.
Conclusions: SeS2 1.8% has the same mycological efficacy and side effect as compared to ketoconazole 2% in the treatment of PV.
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