日本溃疡性结肠炎患者的年龄与便秘相关:一项事后分析

IF 2.1 Q3 GERIATRICS & GERONTOLOGY Gerontology and Geriatric Medicine Pub Date : 2023-11-27 eCollection Date: 2023-01-01 DOI:10.1177/23337214231215637
Sen Yagi, Shinya Furukawa, Teruki Miyake, Osamu Yoshida, Kana Shiraishi, Kazuhiro Tange, Yu Hashimoto, Shogo Kitahata, Tomoyuki Ninomiya, Masakazu Hanayama, Seiyuu Suzuki, Naozumi Shibata, Hidehiro Murakami, Katsuhisa Ohashi, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa
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引用次数: 0

摘要

目的:年龄是便秘的一个危险因素。便秘在溃疡性结肠炎(UC)患者中很常见,并且与疾病活动呈正相关,但证据有限。本研究旨在评估UC患者疾病活动度与便秘之间的关系。方法:研究对象为290例日本UC患者。便秘的定义是基于罗马一号标准和/或治疗便秘的药物。生活习惯的信息来自于一份自我填写的问卷。粘膜愈合(MH)定义为Mayo内镜评分0分。临床缓解(CR)定义为直肠无出血,无异常高大便频率(结果:便秘的患病率与MH、CR、UC持续时间和UC疾病程度无关。70岁年龄组便秘患病率分别为10.0%、5.8%、15.7%、11.8%和25.6%。>70岁与便秘患病率独立正相关(校正优势比3.64[95%可信区间1.26,10.95],p为趋势值:0.001)。结论:年龄与UC中便秘的患病率独立且正相关。
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Aging is Associated With Constipation in Japanese Patients With Ulcerative Colitis: A Post Hoc Analysis.

Aim: Age is a risk factor for constipation. Constipation is common in patients with ulcerative colitis (UC) and has been positively associated with disease activity, but evidence is limited. This study aimed to assess the association between disease activity and constipation in patients with UC. Methods: The study subjects consisted of 290 Japanese UC patients. The definition of constipation was based on Rome I criteria and/or medication for constipation. Information on and lifestyle habits was obtained from a self-administered questionnaire. Mucosal healing (MH) was defined as Mayo endoscopic subscore 0. Clinical remission (CR) was defined as both the absence of rectal bleeding and no abnormally high stool frequency (<3 times per day). Results: The prevalence of constipation is not associated with MH, CR, duration of UC and disease extent of UC. The prevalence of constipation among age groups, <40, 40-49 years, 50-59 years, 60-69 years, and >70 years was 10.0%, 5.8%, 15.7%, 11.8%, and 25.6%, respectively. >70 years was independently and positively associated with the prevalence of constipation (adjusted odds ratio 3.64 [95% confidence interval 1.26, 10.95], p for trend: .001). Conclusions: Aging was independently and positively associated with the prevalence of constipation in UC.

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来源期刊
Gerontology and Geriatric Medicine
Gerontology and Geriatric Medicine Medicine-Geriatrics and Gerontology
CiteScore
2.90
自引率
3.70%
发文量
119
审稿时长
12 weeks
期刊介绍: Gerontology and Geriatric Medicine (GGM) is an interdisciplinary, peer-reviewed open access journal where scholars from a variety of disciplines present their work focusing on the psychological, behavioral, social, and biological aspects of aging, and public health services and research related to aging. The journal addresses a wide variety of topics related to health services research in gerontology and geriatrics. GGM seeks to be one of the world’s premier Open Access outlets for gerontological academic research. As such, GGM does not limit content due to page budgets or thematic significance. Papers will be subjected to rigorous peer review but will be selected solely on the basis of whether the research is sound and deserves publication. By virtue of not restricting papers to a narrow discipline, GGM facilitates the discovery of the connections between papers.
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