PD-1检查点抑制剂治疗黑色素瘤及其他疾病的疗效:外周T细胞表型是关键吗?

IF 4.1 Q2 IMMUNOLOGY Immunotherapy advances Pub Date : 2023-11-22 eCollection Date: 2023-01-01 DOI:10.1093/immadv/ltad026
Katie R Flaherty, Stephanie Kucykowicz, Johannes Schroth, Will Traves, Kyle T Mincham, George E Finney
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引用次数: 0

摘要

免疫疗法治疗策略已被证明对有限部分患者有效,在这些患者中,识别对治疗有反应和无反应仍然是一个挑战。虽然可以从侵入性活检中得出一些适应症,但我们需要更容易获得的方法来预测反应,并在开始治疗之前更好地确定反应的相关性。最近的工作已经确定了对PD-1阻断治疗有反应的黑色素瘤患者外周血基线免疫组成的差异。通过T细胞受体的流式细胞术分析,CD8+和CD4+ T细胞和Tregs的表型特征可以对治疗反应进行分层。分析外周血中的T细胞可能允许在不同癌症治疗前对PD-1治疗反应进行分层。
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Efficacy of PD-1 checkpoint inhibitor therapy in melanoma and beyond: are peripheral T cell phenotypes the key?
Summary Immunotherapy treatment strategies have proven effective in a limited portion of patients, where identifying responders from non-responders to treatment remains a challenge. While some indications can be drawn from invasive biopsies, we need more accessible methods for predicting response and better correlates of response prior to starting therapy. Recent work has identified differences in immune composition at baseline in peripheral blood from melanoma patients responding to PD-1 blockade treatment. Through flow cytometric analysis of T cell receptors, phenotypical features of CD8+ and CD4+ T cells and Tregs could allow for the stratification of treatment response. Analysing T cells within peripheral blood could potentially allow for the stratification of PD-1 treatment response prior to therapy in different cancer settings.
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