心室-动脉耦合分析能否恢复心力衰竭的血流动力学模型?

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2024-03-01 Epub Date: 2023-12-02 DOI:10.1007/s10741-023-10374-7

Johannes Soma

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引用次数: 0

摘要

血流动力学模型不适合解释慢性心力衰竭时血管舒张的令人失望的效果和β -阻滞剂的有益效果。一个更细致的血液动力学分析，考虑到稳定和脉动的血液动力学，提高洞察这些明显神秘的影响。特别有趣的是早期收缩血流速度作为左心室后负荷的决定因素。几种药物，特别是-受体阻滞剂，直接或间接地影响早期收缩血流的速度。因此，心力衰竭的血流动力学模型值得重新考虑。

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Can the hemodynamic model in heart failure be restored based on analysis of ventricular-arterial coupling?

The hemodynamic model was inappropriate to explain the disappointing effect of vasodilation and the beneficial effect of beta-blockade in chronic heart failure. A more nuanced hemodynamic analysis, taking both steady and pulsatile hemodynamics into consideration, improves insight into these apparently enigmatic effects. Of particular interest is the velocity of early systolic flow as a determinant of left ventricular afterload. Several drugs, in particular beta-blockers, directly or indirectly, influence the velocity of early systolic flow. Thus, the hemodynamic model in heart failure may deserve reconsideration.

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.