COVID-19大流行对自身免疫生物学指标时间趋势的影响

IF 4.7 Q2 IMMUNOLOGY Journal of Translational Autoimmunity Pub Date : 2023-12-01 DOI:10.1016/j.jtauto.2023.100222
Elliott Van Regemorter , Giulia Zorzi , Anais Scohy , Damien Gruson , Johann Morelle
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引用次数: 0

摘要

背景和目的2019冠状病毒病(COVID-19)与自身免疫性疾病的发病有关,但这种关系是否存在因果关系尚不清楚,部分原因是缺乏基于自身抗体检测的有力证据。本研究探讨了COVID-19大流行对自身免疫时间趋势的潜在影响。方法回顾性分析2015年1月1日至2022年5月31日在比利时某大学医院的一个中心实验室、其他18家医院和临床实验室进行的所有连续自身免疫检测。分析了自身免疫检测阳性率的纵向变化,即在2019冠状病毒病大流行(2020年3月11日)发生前后。这些检测主要包括检测与1型糖尿病、甲状腺疾病、结缔组织疾病、抗磷脂综合征、血管炎和其他器官特异性疾病相关的自身抗体。采用肯德尔秩相关检验评估时间趋势。结果在89个月的时间里,共对87,674例独特患者(87%为成人,68%为女性,平均年龄44±20岁)进行了24种不同自身抗体的301,720次连续检测。总体而言,52,862例(18%)检测结果呈阳性,每次检测的阳性率在1%至46%之间。大流行开始后,自身免疫试验的阳性率未见增加。结论:COVID-19大流行的发生与大量自身免疫检测的阳性率升高无关。与COVID-19相关的自身免疫性疾病的较高发病率是否反映了检测偏差或反向因果关系,或者是否与血清阴性自身免疫性疾病有关,还需要进一步调查。
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Impact of the COVID-19 pandemic on temporal trends of biological indicators of autoimmunity

Background and objective

Coronavirus Disease 2019 (COVID-19) has been associated with the onset of autoimmune conditions, but whether this relationship is causal remains unknown, partly because robust evidence based on the detection of autoantibodies is lacking. This study explored the potential impact of COVID-19 pandemic on the temporal trends of autoimmunity.

Methods

Retrospective analysis of all consecutive autoimmune tests performed at one central laboratory at a University hospital, operating services for 18 other hospitals and clinical laboratories in Belgium, from January 01, 2015 to May 31, 2022. Longitudinal changes in the positivity rates of autoimmunity tests were analyzed, i.e. before and after the onset of the COVID-19 pandemic (March 11, 2020). The tests notably included the detection of autoantibodies associated with type 1 diabetes, thyroid diseases, connective tissue diseases, antiphospholipid syndrome, vasculitis and other organ-specific conditions. Kendall rank correlation test was applied to assess temporal trends.

Results

Over a period of 89 months, a total of 301,720 consecutive tests for 24 different autoantibodies among 87,674 unique patients were performed (87% adults, 68% women, mean age 44 ± 20 years). Overall, 52,862 (18%) tests returned positive, with positivity rates for each test ranging between 1% and 46%. No increase in the positivity rate of autoimmunity tests was observed after the start of the pandemic.

Conclusion

The onset of the COVID-19 pandemic was not associated with increased positivity rates of a large panel of autoimmune tests. Whether the higher incidence of autoimmune disorders associated with COVID-19 reflects detection bias or reverse causality, or is linked to seronegative autoimmune disorders requires further investigation.

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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
期刊最新文献
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