日本老年人肺活量保持率受损的痴呆风险:Hisayama研究

IF 3.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Epidemiology Pub Date : 2024-07-05 Epub Date: 2024-04-30 DOI:10.2188/jea.JE20230207
Kenji Kawatoko, Yasuyoshi Washio, Tomoyuki Ohara, Satoru Fukuyama, Takanori Honda, Jun Hata, Taro Nakazawa, Keiko Kan-O, Hiromasa Inoue, Koichiro Matsumoto, Tomohiro Nakao, Takanari Kitazono, Isamu Okamoto, Toshiharu Ninomiya
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引用次数: 0

摘要

背景:关于保留比例肺功能受损(PRISm)与痴呆之间关系的研究有限。的确,PRISm作为肺功能损害的指标经常被忽视或忽视。因此,我们调查了PRISm与老年日本人群痴呆风险的关系。方法:对1202名≥65岁无痴呆的日本社区老年人进行随访,随访时间中位数为5.0年。受试者按肺活量计进行分类:正常肺活量计(FEV1/FVC≥0.70,FEV1≥80%预测值),PRISm(≥0.70)。结果:随访期间,122名受试者发生痴呆。在肺活量、PRISm、AFL GOLD 1和AFL GOLD 2至4正常的参与者中,经年龄和性别调整的痴呆发病率分别为20.5、37.0、18.4和28.6 / 1000人年。校正混杂因素后,PRISm患者的痴呆风险高于肺量测定正常患者(HR 2.04 [95%CI, 1.19-3.49])。此外,FEV1%预测值和FVC%预测值均与痴呆风险相关。结论:PRISm与日本普通老年人患痴呆的风险增加有关。
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Risks of Dementia in a General Japanese Older Population With Preserved Ratio Impaired Spirometry: The Hisayama Study.

Background: Studies on the association between preserved ratio impaired spirometry (PRISm) and dementia are limited. Indeed, PRISm has often been overlooked or ignored as an index of lung function impairment. Therefore, we investigated the association of PRISm with the risk for the development of dementia in an older Japanese population.

Methods: A total of 1,202 community-dwelling, older Japanese participants aged ≥65 years without dementia were followed up for a median of 5.0 years. Participants were categorized by spirometry as follows: normal spirometry (FEV1/FVC ≥0.70 and FEV1 ≥80% predicted), PRISm (≥0.70 and <80%), airflow limitation (AFL) Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 (<0.70 and ≥80%), and AFL GOLD 2 to 4 (<0.70 and <80%). Hazard ratios (HRs) and their 95% confidence intervals (CIs) were computed using a Cox proportional hazards model.

Results: During the follow-up period, 122 participants developed dementia. The age- and sex-adjusted incidences of dementia in the participants with normal spirometry, PRISm, AFL GOLD 1, and AFL GOLD 2 to 4 were 20.5, 37.0, 18.4, and 28.6 per 1,000 person-years, respectively. Participants with PRISm had a higher risk of dementia (HR 2.04; 95% CI, 1.19-3.49) than those with normal spirometry after adjusting for confounders. Moreover, both reduced FEV1% predicted values and FVC% predicted values were associated with the risk of dementia.

Conclusion: PRISm was associated with an increased risk of dementia in a general older Japanese population.

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来源期刊
Journal of Epidemiology
Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
7.50
自引率
4.30%
发文量
172
审稿时长
6-12 weeks
期刊介绍: The Journal of Epidemiology is the official open access scientific journal of the Japan Epidemiological Association. The Journal publishes a broad range of original research on epidemiology as it relates to human health, and aims to promote communication among those engaged in the field of epidemiological research and those who use epidemiological findings.
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