骨诱导鳞状细胞癌与推测的新型乳头状瘤病毒在猫的手指。

IF 1.1 4区 农林科学 Q3 VETERINARY SCIENCES New Zealand veterinary journal Pub Date : 2024-03-01 Epub Date: 2024-02-04 DOI:10.1080/00480169.2023.2285294
J S Munday, M E Dunbar, P Wightman, S Piripi
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引用次数: 0

摘要

病例史和临床表现:一只大约10岁,阉割的雄性家养短毛猫右前爪第二趾肿胀和溃疡。x线片显示球形软组织肿胀,远端边缘不规则,包含多个花边矿物混浊。手指被截肢并提交组织学检查。截肢后7个月未见复发。病理和分子检查结果:组织学显示在小梁和巢中排列的分化良好的鳞状细胞增殖。肿瘤内可见大量骨化生的细针状物。约70%的肿瘤细胞含有乳头瘤病毒诱导的细胞改变,包括大的嗜两性细胞质体和细胞核被清晰晕包围的萎缩细胞。肿瘤细胞内可见强烈的p16CDKN2A蛋白免疫染色,提示乳头瘤病毒诱导的细胞调节变化。从肿瘤中扩增出推定的新型陶乳头瘤病毒类型的DNA序列。诊断:骨诱导性鳞状细胞癌与推测的新型乳头瘤病毒类型相关。临床相关性:本病例的发现增加了已知感染猫的乳头状瘤病毒类型的数量,并且鳞状细胞癌具有以前未报道的组织学特征。该肿瘤不像典型的鳞状细胞癌那样具有侵袭性,切除似乎可以治愈。本文首次报道猫皮肤骨诱导性鳞状细胞癌,该肿瘤具有独特的影像学表现。
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Osteoinductive squamous cell carcinoma associated with a putative novel papillomavirus on the digit of a cat.

Case history and clinical findings: An approximately 10-year-old, castrated male domestic short-haired cat developed swelling and ulceration of the second digit of the right front paw. Radiographs revealed a spherical soft tissue swelling with irregular distal margins that contained multiple lacy mineral opacities. The digit was amputated and submitted for histology. No recurrence has been observed 7 months after amputation.

Pathological and molecular findings: Histology revealed a moderately well-circumscribed proliferation of well-differentiated squamous cells arranged in trabeculae and nests. Numerous thin spicules of osseous metaplasia were visible throughout the neoplasm. Around 70% of the neoplastic cells contained papillomavirus-induced cell changes including large amphophilic cytoplasmic bodies and cells with shrunken nuclei surrounded by a clear halo. Intense p16CDKN2A protein immunostaining was visible within the neoplastic cells, suggesting papillomavirus-induced changes in cell regulation. A DNA sequence from a putative novel Taupapillomavirus type was amplified from the neoplasm.

Diagnosis: Osteoinductive squamous cell carcinoma associated with a putative novel papillomavirus type.

Clinical relevance: The findings in this case increase the number of papillomavirus types known to infect cats, and the squamous cell carcinoma had histological features that have not been previously reported. The neoplasm was not as invasive as is typical for a squamous cell carcinoma and excision appeared curative. This is the first report of an osteoinductive squamous cell carcinoma of the skin of cats and the neoplasm had a unique radiographic appearance.

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来源期刊
New Zealand veterinary journal
New Zealand veterinary journal 农林科学-兽医学
CiteScore
3.00
自引率
0.00%
发文量
37
审稿时长
12-24 weeks
期刊介绍: The New Zealand Veterinary Journal (NZVJ) is an international journal publishing high quality peer-reviewed articles covering all aspects of veterinary science, including clinical practice, animal welfare and animal health. The NZVJ publishes original research findings, clinical communications (including novel case reports and case series), rapid communications, correspondence and review articles, originating from New Zealand and internationally. Topics should be relevant to, but not limited to, New Zealand veterinary and animal science communities, and include the disciplines of infectious disease, medicine, surgery and the health, management and welfare of production and companion animals, horses and New Zealand wildlife. All submissions are expected to meet the highest ethical and welfare standards, as detailed in the Journal’s instructions for authors.
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