将视网膜映射到大脑。

IF 6.9 2区 生物学 Q1 CELL BIOLOGY Cold Spring Harbor perspectives in biology Pub Date : 2024-02-01 DOI:10.1101/cshperspect.a041512
Daniel Kerschensteiner, Marla B Feller
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引用次数: 0

摘要

视觉始于视网膜,视网膜从环境中提取显著特征,并将其编码到视网膜神经节细胞(RGC)的尖峰序列中,RGC 是眼睛的输出神经元。视网膜神经节细胞轴突支配不同的脑区(小鼠大于 50 个),以支持感知、引导行为,并介导光对生理和内部状态的影响。近年来,我们编制了完整的 RGC 类型列表(小鼠为 45 种),绘制了详细的树突连接图,并按比例调查了它们的光反应。我们对将视网膜信息映射到大脑的 RGC 轴突投射模式了解较少。不过,一些组织原则已经出现。在这里,我们回顾了支配发育中的RGC轴突并组织它们支配视网膜相关脑区的策略和机制。
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Mapping the Retina onto the Brain.

Vision begins in the retina, which extracts salient features from the environment and encodes them in the spike trains of retinal ganglion cells (RGCs), the output neurons of the eye. RGC axons innervate diverse brain areas (>50 in mice) to support perception, guide behavior, and mediate influences of light on physiology and internal states. In recent years, complete lists of RGC types (∼45 in mice) have been compiled, detailed maps of their dendritic connections drawn, and their light responses surveyed at scale. We know less about the RGCs' axonal projection patterns, which map retinal information onto the brain. However, some organizing principles have emerged. Here, we review the strategies and mechanisms that govern developing RGC axons and organize their innervation of retinorecipient brain areas.

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来源期刊
CiteScore
15.00
自引率
1.40%
发文量
56
审稿时长
3-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.
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