根据神经内分泌肿瘤患者的性别划分体生长抑素类似物的疗效和耐受性。

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 Epub Date: 2023-12-05 DOI:10.1007/s11154-023-09858-6
Rosaria M Ruggeri, Irene Aini, Stefano Gay, Erika Maria Grossrubatscher, Camilla Mancini, Maria Grazia Tarsitano, Virginia Zamponi, Andrea M Isidori, Annamaria Colao, Antongiulio Faggiano
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引用次数: 0

摘要

随着神经内分泌肿瘤发病率的不断上升,流行病学和临床行为的性别差异已经显现,对这些肿瘤的性别驱动管理的兴趣越来越大,目的是提高这些患者的生存率和生活质量。生长抑素类似物通过在肿瘤细胞中表达生长抑素受体(SSTRs),成为功能性和非功能性神经内分泌肿瘤系统治疗的第一线药物,已被证明可有效控制激素高分泌,抑制肿瘤生长,提高患者的无进展生存期和总生存期。本综述的目的是调查ssts靶向治疗在疗效和安全性方面的性别差异,ssts靶向治疗是神经内分泌肿瘤的主要治疗方法,因为它们来自不同设计和意图的研究。尽管临床前研究已经提供了支持SSTR肿瘤表达的性别差异以及性激素和相关受体在调节SSTR表达和功能中的作用的证据,但迄今为止进行的临床研究尚未显示男性和女性在SSTR靶向治疗的疗效或毒性方面存在实质性差异,即使有时结果不一致。此外,在大多数研究中,性别并不是对治疗反应的预测因子。需要专门针对这一问题设计的研究,以开发针对性别的治疗算法,改善患者的预后和生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors.

As the incidence of neuroendocrine tumors has been rising, gender differences in epidemiology and clinical behavior have emerged, and interest into a gender-driven management of these tumors has grown with the aim to improve survival and quality of life of these patients. Somatostatin Analogues represent the first line of systemic treatment of both functional and non-functional neuroendocrine tumors, through the expression of somatostatin receptors (SSTRs) in the tumor cells, and proved effective in controlling hormonal hypersecretion and inhibiting tumor growth, improving progression-free survival and overall survival of these patients. Aim of the present review is to investigate any differences by gender in efficacy and safety of SSTS-targeted therapies, that represent the mainstay treatment of neuroendocrine tumors, as they emerge from studies of varying design and intent. Although preclinical studies have provided evidence in favor of differences by gender in tumor expression of SSTR, as well as of the role of sex hormones and related receptors in modulating SSTRs expression and function, the clinical studies conducted so far have not shown substantial differences between males and females in either efficacy or toxicity of SSTR-targeted therapies, even if with sometimes inconsistent results. Moreover, in most studies gender was not a predictor of response to treatment. Studies specifically designed to address this issue are needed to develop gender-specific therapeutic algorithms, improving patients' prognosis and quality of life.

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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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