Morten Bentestuen MD , Surenth Nalliah MD , Marie M.K. Stolberg MD , Helle D. Zacho MD, PhD, DMSc
{"title":"如何进行 FAPI PET?快速系统综述为使用不同 FAPI 示踪剂进行 FAPI PET 成像提供建议。","authors":"Morten Bentestuen MD , Surenth Nalliah MD , Marie M.K. Stolberg MD , Helle D. Zacho MD, PhD, DMSc","doi":"10.1053/j.semnuclmed.2023.11.003","DOIUrl":null,"url":null,"abstract":"<div><p>This expedited systematic review aims to provide the first overview of the different Fibroblast activation protein inhibitor (FAPI) PET scan procedures in the literature and discuss how to efficiently obtain optimal FAPI PET images based on the best available evidence. The PubMed, Embase, Cochrane Library, and Web of Science databases were systematically searched in April 2023. Peer-reviewed cohort studies published in English and used FAPI tracers were included. Articles were excluded if critical scan procedure information was missing, or the article was not retrievable from a university library within 30 days. Data were grouped according to the FAPI tracer applied. Meta-analysis with proper statistics was deemed not feasible based on a pilot study. A total of 946 records were identified. After screening, 159 studies were included. [<sup>68</sup>Ga]Ga-FAPI-04 was applied in 98 studies (61%), followed by [<sup>68</sup>Ga]Ga-FAPI-46 in 19 studies (12%). Most studies did not report specific patient preparation. A mean/median administered activity of 80-200 MBq was most common; however, wide ranges were seen in [<sup>68</sup>Ga]Ga-FAPI-04 PET studies (56-370 MBq). An injection-to-scan-time of 60 minutes was dominant for all FAPI PET studies. A possible trend toward shorter injection-to-scan times was observed for [<sup>68</sup>Ga]Ga-FAPI-46. Three studies evaluated [<sup>68</sup>Ga]Ga-FAPI-46 PET acquisition at multiple time points in more than 593 cancer lesions, all yielding equivalent tumor detection at 10 minutes vs later time points despite slightly lower tumor-to-background Ratios. Despite the wide ranges, most institutions administer an average of 80-200 MBq [<sup>68</sup>Ga]Ga-FAPI-04/46 and scan patients at 60 minutes postinjection. For [<sup>68</sup>Ga]Ga-FAPI-46, the present evidence consistently supports the feasibility of image acquisition earlier than 30 minutes. Currently, data on the optimal FAPI PET scan procedure are limited, and more studies are encouraged. The current review can serve as a temporary guideline for institutions planning FAPI PET studies.</p></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0001299823000922/pdfft?md5=c78c3466dc48bfe83d31835ae2d9b453&pid=1-s2.0-S0001299823000922-main.pdf","citationCount":"0","resultStr":"{\"title\":\"How to Perform FAPI PET? An Expedited Systematic Review Providing a Recommendation for FAPI PET Imaging With Different FAPI Tracers\",\"authors\":\"Morten Bentestuen MD , Surenth Nalliah MD , Marie M.K. Stolberg MD , Helle D. Zacho MD, PhD, DMSc\",\"doi\":\"10.1053/j.semnuclmed.2023.11.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This expedited systematic review aims to provide the first overview of the different Fibroblast activation protein inhibitor (FAPI) PET scan procedures in the literature and discuss how to efficiently obtain optimal FAPI PET images based on the best available evidence. The PubMed, Embase, Cochrane Library, and Web of Science databases were systematically searched in April 2023. Peer-reviewed cohort studies published in English and used FAPI tracers were included. Articles were excluded if critical scan procedure information was missing, or the article was not retrievable from a university library within 30 days. Data were grouped according to the FAPI tracer applied. Meta-analysis with proper statistics was deemed not feasible based on a pilot study. A total of 946 records were identified. After screening, 159 studies were included. [<sup>68</sup>Ga]Ga-FAPI-04 was applied in 98 studies (61%), followed by [<sup>68</sup>Ga]Ga-FAPI-46 in 19 studies (12%). Most studies did not report specific patient preparation. A mean/median administered activity of 80-200 MBq was most common; however, wide ranges were seen in [<sup>68</sup>Ga]Ga-FAPI-04 PET studies (56-370 MBq). An injection-to-scan-time of 60 minutes was dominant for all FAPI PET studies. A possible trend toward shorter injection-to-scan times was observed for [<sup>68</sup>Ga]Ga-FAPI-46. Three studies evaluated [<sup>68</sup>Ga]Ga-FAPI-46 PET acquisition at multiple time points in more than 593 cancer lesions, all yielding equivalent tumor detection at 10 minutes vs later time points despite slightly lower tumor-to-background Ratios. Despite the wide ranges, most institutions administer an average of 80-200 MBq [<sup>68</sup>Ga]Ga-FAPI-04/46 and scan patients at 60 minutes postinjection. For [<sup>68</sup>Ga]Ga-FAPI-46, the present evidence consistently supports the feasibility of image acquisition earlier than 30 minutes. Currently, data on the optimal FAPI PET scan procedure are limited, and more studies are encouraged. The current review can serve as a temporary guideline for institutions planning FAPI PET studies.</p></div>\",\"PeriodicalId\":21643,\"journal\":{\"name\":\"Seminars in nuclear medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0001299823000922/pdfft?md5=c78c3466dc48bfe83d31835ae2d9b453&pid=1-s2.0-S0001299823000922-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in nuclear medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0001299823000922\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in nuclear medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0001299823000922","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
本快速系统综述旨在首次概述文献中不同的成纤维细胞活化蛋白抑制剂(FAPI)PET 扫描程序,并讨论如何根据现有的最佳证据有效地获得最佳 FAPI PET 图像。2023 年 4 月,对 PubMed、Embase、Cochrane Library 和 Web of Science 数据库进行了系统检索。纳入了使用 FAPI 示踪剂的经同行评审的英文发表的队列研究。如果关键扫描程序信息缺失,或文章无法在 30 天内从大学图书馆检索到,则文章将被排除在外。根据所使用的 FAPI 示踪剂对数据进行分组。根据一项试验性研究的结果,使用适当的统计数据进行元分析被认为是不可行的。共确定了 946 条记录。经过筛选,共纳入 159 项研究。98项研究(61%)应用了[68Ga]Ga-FAPI-04,19项研究(12%)应用了[68Ga]Ga-FAPI-46。大多数研究没有报告患者的具体准备情况。最常见的是 80-200 MBq 的平均/中值给药活性;不过,[68Ga]Ga-FAPI-04 PET 研究中也出现了较大的范围(56-370 MBq)。在所有 FAPI PET 研究中,注射到扫描时间主要为 60 分钟。[68Ga]Ga-FAPI-46的注射到扫描时间可能有缩短的趋势。三项研究评估了在多个时间点对超过 593 个癌症病灶进行[68Ga]Ga-FAPI-46 PET 采集的情况,尽管肿瘤与背景比率略低,但所有研究在 10 分钟与稍后时间点的肿瘤检测结果相当。尽管范围很广,但大多数机构平均注射 80-200 MBq [68Ga]Ga-FAPI-04/46 并在注射后 60 分钟对患者进行扫描。对于[68Ga]Ga-FAPI-46,目前的证据一致支持提前 30 分钟采集图像的可行性。目前,有关最佳 FAPI PET 扫描程序的数据还很有限,我们鼓励进行更多的研究。本综述可作为计划进行 FAPI PET 研究的机构的临时指南。
How to Perform FAPI PET? An Expedited Systematic Review Providing a Recommendation for FAPI PET Imaging With Different FAPI Tracers
This expedited systematic review aims to provide the first overview of the different Fibroblast activation protein inhibitor (FAPI) PET scan procedures in the literature and discuss how to efficiently obtain optimal FAPI PET images based on the best available evidence. The PubMed, Embase, Cochrane Library, and Web of Science databases were systematically searched in April 2023. Peer-reviewed cohort studies published in English and used FAPI tracers were included. Articles were excluded if critical scan procedure information was missing, or the article was not retrievable from a university library within 30 days. Data were grouped according to the FAPI tracer applied. Meta-analysis with proper statistics was deemed not feasible based on a pilot study. A total of 946 records were identified. After screening, 159 studies were included. [68Ga]Ga-FAPI-04 was applied in 98 studies (61%), followed by [68Ga]Ga-FAPI-46 in 19 studies (12%). Most studies did not report specific patient preparation. A mean/median administered activity of 80-200 MBq was most common; however, wide ranges were seen in [68Ga]Ga-FAPI-04 PET studies (56-370 MBq). An injection-to-scan-time of 60 minutes was dominant for all FAPI PET studies. A possible trend toward shorter injection-to-scan times was observed for [68Ga]Ga-FAPI-46. Three studies evaluated [68Ga]Ga-FAPI-46 PET acquisition at multiple time points in more than 593 cancer lesions, all yielding equivalent tumor detection at 10 minutes vs later time points despite slightly lower tumor-to-background Ratios. Despite the wide ranges, most institutions administer an average of 80-200 MBq [68Ga]Ga-FAPI-04/46 and scan patients at 60 minutes postinjection. For [68Ga]Ga-FAPI-46, the present evidence consistently supports the feasibility of image acquisition earlier than 30 minutes. Currently, data on the optimal FAPI PET scan procedure are limited, and more studies are encouraged. The current review can serve as a temporary guideline for institutions planning FAPI PET studies.
期刊介绍:
Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.