阿磷脂酸胆碱与银杏叶单药联合疗法治疗老年性听力损失：效果与结果。

IF 1.1 Q3 OTORHINOLARYNGOLOGY Journal of Audiology and Otology Pub Date : 2023-01-01 Epub Date: 2023-12-07 DOI:10.7874/jao.2023.00192

Dae Hyun Kim, Young Joon Seo

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引用次数: 0

摘要

背景和目的：：银杏叶和阿佛斯甘酸胆碱被用作老花眼的辅助治疗，但缺乏有关单一疗法与联合疗法有何不同的研究。因此，本研究旨在比较银杏叶单一疗法与银杏叶和阿磷脂酸胆碱联合疗法的听力效果：研究组分为三组：阴性对照组、单一疗法组和联合疗法组。将研究期间分为初始、3-6、6-9、9-12、12-15 个月，测量各组的纯音听力，并检查各组之间是否存在差异：结果：联合疗法的梯度差距小于单一疗法，表明听力损失率低于单一疗法。根据卡普兰-梅耶曲线，联合疗法在听力存活时间方面显示出更好的效果：结论：作为老花眼的药物治疗，联合疗法比单一疗法效果更好。

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Combination Therapy of Choline Alfoscerate With Ginkgo biloba Monotherapy in Age-Related Hearing Loss: Effects and Outcomes.

Background and objectives: Ginkgo biloba and choline alfoscerate are used as adjuvant treatment for presbycusis, but studies on how the monotherapy differs from the combination therapy are lacking. Therefore, this study aimed to compare the audiologic outcomes between Ginkgo biloba monotherapy and Ginkgo biloba and choline alfoscerate combination therapy. Subjects and.

Methods: The study groups are divided into three: negative control, monotherapy, and combination therapy groups. All groups' pure tone audiometry was measured by dividing the study period into Initial, 3-6, 6-9, 9-12, 12-15 months, and checked whether differences between groups were present.

Results: The combination therapy showed less gradient gap than the monotherapy, indicating less hearing loss rate than the monotherapy. Based on the Kaplan-Meier curve, the combination therapy showed better results in terms of survival time of hearing.

Conclusions: As a pharmacological treatment for presbycusis, combination therapy shows better results than monotherapy.

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来源期刊

Journal of Audiology and Otology OTORHINOLARYNGOLOGY-

CiteScore

1.90

自引率

9.10%

发文量

期刊介绍： Journal of Audiology and Otology (JAO) (formerly known as Korean Journal of Audiology) aims to publish the most advanced findings for all aspects of the auditory and vestibular system and diseases of the ear using state-of-the-art techniques and analyses. The journal covers recent trends related to the topics of audiology, otology, and neurotology conducted by professionals, with the goal of providing better possible treatment to people of all ages, from infants to the elderly, who suffer from auditory and/or vestibular disorders and thus, improving their quality of life. This journal encourages the submission of review papers about current professional issues, research papers presenting a scientific base and clinical application, and case papers with unique reports or clinical trials. We also invite letters to the editor and papers related to the manufacture and distribution of medical devices. This journal provides integrated views from otologists, audiologists, and other healthcare practitioners, offering readers high quality scientific and clinical information. This peer-reviewed and open access journal has been the official journal of the Korean Audiological Society since 1997 and of both the Korean Audiological Society and the Korean Otological Society since 2017. It is published in English four times a year in January, April, July, and October.