靶向肿瘤微环境中脂质代谢失调。

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL Archives of Pharmacal Research Pub Date : 2023-12-07 DOI:10.1007/s12272-023-01473-y
Do-Hee Kim, Na-Young Song, Hyungshin Yim
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引用次数: 0

摘要

脂质代谢的重编程及其与肿瘤微环境(TME)中致癌信号通路的关联已成为癌症的重要标志。脂质代谢被定义为一系列复杂的分子过程,包括脂质摄取、合成、转运和降解。脂质代谢的失调受直接或间接参与脂质代谢过程的酶和信号分子的影响。脂质代谢酶的调节已被证明可以调节肿瘤的发展并避免肿瘤和TME对抗癌药物的耐药性。正因为如此,了解与致癌进展相关的代谢重编程对于制定癌症治疗策略非常重要。最近的进展提供了洞察基本机制和改变脂质代谢和肿瘤发生之间的联系。在这篇综述中,我们探讨了脂质代谢的改变和驱动脂质代谢重编程的关键因素,这些因素加剧了癌症的进展。我们还阐明了基于靶向脂质代谢的小分子抑制剂和植物化学物质的最新见解和当前治疗方法。为了充分了解脂质代谢改变与癌变之间的潜在机制和相关性,进一步的研究是值得的。
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Targeting dysregulated lipid metabolism in the tumor microenvironment

The reprogramming of lipid metabolism and its association with oncogenic signaling pathways within the tumor microenvironment (TME) have emerged as significant hallmarks of cancer. Lipid metabolism is defined as a complex set of molecular processes including lipid uptake, synthesis, transport, and degradation. The dysregulation of lipid metabolism is affected by enzymes and signaling molecules directly or indirectly involved in the lipid metabolic process. Regulation of lipid metabolizing enzymes has been shown to modulate cancer development and to avoid resistance to anticancer drugs in tumors and the TME. Because of this, understanding the metabolic reprogramming associated with oncogenic progression is important to develop strategies for cancer treatment. Recent advances provide insight into fundamental mechanisms and the connections between altered lipid metabolism and tumorigenesis. In this review, we explore alterations to lipid metabolism and the pivotal factors driving lipid metabolic reprogramming, which exacerbate cancer progression. We also shed light on the latest insights and current therapeutic approaches based on small molecular inhibitors and phytochemicals targeting lipid metabolism for cancer treatment. Further investigations are worthwhile to fully understand the underlying mechanisms and the correlation between altered lipid metabolism and carcinogenesis.

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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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