进行性共济失调和腭震颤与IgLON5抗体无关:两例结果

IF 2.7 3区医学 Q3 NEUROSCIENCES Cerebellum Pub Date : 2024-08-01 Epub Date: 2023-12-07 DOI:10.1007/s12311-023-01647-w

Andrea Mastrangelo, Maria Pia Giannoccaro, Vincenzo Donadio, Fortuna Ricciardiello, Felice Di Laudo, Flavia Palombo, Rocco Liguori, Giovanni Rizzo

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引用次数: 0

摘要

进行性共济失调和腭震颤(PAPT)和抗iglon5疾病具有可能的临床表现。此外，两者都与主要影响脑干的牛头病有关。尽管如此，抗iglon5抗体从未在PAPT中检测过。我们报告了两例PAPT病例，脑脊液和血清中均未发现抗iglon5抗体。尽管有共同的临床和病理特征，PAPT和IgLON5疾病是两个不同的实体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Progressive Ataxia and Palatal Tremor Is Not Associated with IgLON5 Antibodies: Results From Two Cases.

Progressive ataxia and palatal tremor (PAPT) and anti-IgLON5 disease share possible clinical presentations. Furthermore, both have been associated to a tauopathy mainly affecting the brainstem. Nonetheless, anti-IgLON5 antibodies have never been tested in PAPT. We report on two PAPT cases without evidence of anti-IgLON5 antibodies in both CSF and serum. Despite common clinical and pathological characteristics, PAPT and IgLON5 disease are two distinct entities.

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来源期刊

Cerebellum 医学-神经科学

CiteScore

6.40

自引率

14.30%

发文量

150

审稿时长

4-8 weeks

期刊介绍： Official publication of the Society for Research on the Cerebellum devoted to genetics of cerebellar ataxias, role of cerebellum in motor control and cognitive function, and amid an ageing population, diseases associated with cerebellar dysfunction. The Cerebellum is a central source for the latest developments in fundamental neurosciences including molecular and cellular biology; behavioural neurosciences and neurochemistry; genetics; fundamental and clinical neurophysiology; neurology and neuropathology; cognition and neuroimaging. The Cerebellum benefits neuroscientists in molecular and cellular biology; neurophysiologists; researchers in neurotransmission; neurologists; radiologists; paediatricians; neuropsychologists; students of neurology and psychiatry and others.