先前的压力行为控制经验有助于社会支配

IF 4.3 2区 医学 Q1 NEUROSCIENCES Neurobiology of Stress Pub Date : 2023-12-06 DOI:10.1016/j.ynstr.2023.100597
Philip T. Coleman , Gabriel W. Costanza-Chavez , Heather N. Martin, Jose Amat, Matthew G. Frank, Rory J. Sanchez, Garrett J. Potter, Simone M. Mellert, Rene K. Carter, Gianni N. Bonnici, Steven F. Maier, Michael V. Baratta
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引用次数: 0

摘要

支配地位对身心健康有广泛的影响,个体的相对地位可由经验因素塑造。各种各样的考虑表明,对压力源的行为控制的经验应该产生优势测试的胜利,并且胜利应该减弱后压力源的影响,就像先前的控制一样。为了研究竞争成功与压力源控制之间的相互作用,我们首先在一个改良的大鼠温点竞争测试中研究了压力源可控性对随后表现的影响。先前的可控经验,但不是物理上相同的不可控,压力增加了后来的努力行为和占领温暖点。可控压力组的排名始终高于不可控压力组。在行为控制期间,前边缘(PL)皮层的药理学失活阻止了后来的优势化。接下来,我们探讨了重复的胜利经历是否会产生后来对不可控制的压力的典型后遗症的抵抗力。为了建立优势地位,给三联大鼠进行5次温点竞争。背内侧纹状体中PL或NMDA受体阻断的可逆失活阻止了稳定优势的发展。稳定的胜利减弱了后期压力引起的中缝背核血清素活性的增加,并阻止了无法控制的压力引起的社会回避。相比之下,内分泌和神经免疫对不可控压力的反应不受影响,表明先前优势的选择性影响。总之,这些数据表明,对压力的工具控制促进了后来的支配地位,但也揭示了胜利的经历缓冲了未来逆境的神经和行为结果。
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Prior experience with behavioral control over stress facilitates social dominance

Dominance status has extensive effects on physical and mental health, and an individual's relative position can be shaped by experiential factors. A variety of considerations suggest that the experience of behavioral control over stressors should produce winning in dominance tests and that winning should blunt the impact of later stressors, as does prior control. To investigate the interplay between competitive success and stressor control, we first examined the impact of stressor controllability on subsequent performance in a warm spot competition test modified for rats. Prior experience of controllable, but not physically identical uncontrollable, stress increased later effortful behavior and occupation of the warm spot. Controllable stress subjects consistently ranked higher than did uncontrollable stress subjects. Pharmacological inactivation of the prelimbic (PL) cortex during behavioral control prevented later facilitation of dominance. Next, we explored whether repeated winning experiences produced later resistance against the typical sequelae of uncontrollable stress. To establish dominance status, triads of rats were given five sessions of warm spot competition. The development of stable dominance was prevented by reversible inactivation of the PL or NMDA receptor blockade in the dorsomedial striatum. Stable winning blunted the later stress-induced increase in dorsal raphe nucleus serotonergic activity, as well as prevented uncontrollable stress-induced social avoidance. In contrast, endocrine and neuroimmune responses to uncontrollable stress were unaffected, indicating a selective impact of prior dominance. Together, these data demonstrate that instrumental control over stress promotes later dominance, but also reveal that winning experiences buffer against the neural and behavioral outcomes of future adversity.

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来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
期刊最新文献
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