Modeling the Regeneration of Human Skin and Hair Follicles in a Full-Thickness Xenograft

Abstract

Xenotransplantation of human skin to mice with immunodeficiency is one of the most adequate models for studying the mechanisms of regeneration and, thus, it opens up broad prospects for research in the fields of modern cell biology and regenerative medicine. The full-thickness skin strip xenotransplantation model developed in our laboratory allowed us to describe the dynamics of restoration of the human dermis and subcutaneous adipose tissue. Expression and activation of YAP1 protein during regeneration of epidermis, hair follicles (HF), and papillary dermis (PD) was investigated, on the basis of which assumptions were made about the nature of some cellular and molecular processes during the regeneration of human skin.