基因组变异调用的FPGA加速器

IF 3.1 4区计算机科学 Q2 COMPUTER SCIENCE, HARDWARE & ARCHITECTURE ACM Transactions on Reconfigurable Technology and Systems Pub Date : 2023-05-22 DOI:https://dl.acm.org/doi/10.1145/3595297

Tiancheng Xu, Scott Rixner, Alan L. Cox

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引用次数: 0

摘要

在基因组分析中，从参考基因组中识别变异通常是很重要的。然而，识别频率较低的变体可能具有挑战性，因为要准确地做到这一点需要大量的计算。LoFreq是一个广泛使用的程序，擅长识别低频变异。本文提出了一种基于fpga的LoFreq加速器的设计框架。特别是，该加速器针对的是病毒分析，与人类基因组分析相比，病毒分析尤其具有挑战性，因为待分析数据的特征根本不同。在整个设计空间中，该加速器可以在LoFreq的核心计算上实现高达120倍的加速，并在整个程序中实现高达51.7倍的加速。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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An FPGA Accelerator for Genome Variant Calling

In genome analysis, it is often important to identify variants from a reference genome. However, identifying variants that occur with low frequency can be challenging, as it is computationally intensive to do so accurately. LoFreq is a widely used program that is adept at identifying low frequency variants. This paper presents a design framework for an FPGA-based accelerator for LoFreq. In particular, this accelerator is targeted at virus analysis, which is particularly challenging, compared to human genome analysis, as the characteristics of the data to be analyzed are fundamentally different. Across the design space, this accelerator can achieve up to 120 × speedups on the core computation of LoFreq and speedups of up to 51.7 × across the entire program.

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来源期刊

ACM Transactions on Reconfigurable Technology and Systems COMPUTER SCIENCE, HARDWARE & ARCHITECTURE-

CiteScore

4.90

自引率

8.70%

发文量

审稿时长

>12 weeks

期刊介绍： TRETS is the top journal focusing on research in, on, and with reconfigurable systems and on their underlying technology. The scope, rationale, and coverage by other journals are often limited to particular aspects of reconfigurable technology or reconfigurable systems. TRETS is a journal that covers reconfigurability in its own right. Topics that would be appropriate for TRETS would include all levels of reconfigurable system abstractions and all aspects of reconfigurable technology including platforms, programming environments and application successes that support these systems for computing or other applications. -The board and systems architectures of a reconfigurable platform. -Programming environments of reconfigurable systems, especially those designed for use with reconfigurable systems that will lead to increased programmer productivity. -Languages and compilers for reconfigurable systems. -Logic synthesis and related tools, as they relate to reconfigurable systems. -Applications on which success can be demonstrated. The underlying technology from which reconfigurable systems are developed. (Currently this technology is that of FPGAs, but research on the nature and use of follow-on technologies is appropriate for TRETS.) In considering whether a paper is suitable for TRETS, the foremost question should be whether reconfigurability has been essential to success. Topics such as architecture, programming languages, compilers, and environments, logic synthesis, and high performance applications are all suitable if the context is appropriate. For example, an architecture for an embedded application that happens to use FPGAs is not necessarily suitable for TRETS, but an architecture using FPGAs for which the reconfigurability of the FPGAs is an inherent part of the specifications (perhaps due to a need for re-use on multiple applications) would be appropriate for TRETS.