2019冠状病毒病疫情下的智能刺激反应性药物输送系统

IF 10.7 1区 医学 Q1 PHARMACOLOGY & PHARMACY Asian Journal of Pharmaceutical Sciences Pub Date : 2023-11-01 DOI:10.1016/j.ajps.2023.100873
Zeinab Najjari, Farzaneh Sadri, Jaleh Varshosaz
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引用次数: 0

摘要

自2019年底以来,世界一直在应对一种新型严重急性呼吸系统综合征(SARS-CoV-2),威胁着全世界许多人的生命。COVID-19引起的呼吸道感染有不同的症状,从打喷嚏和咳嗽到肺炎,有时还会出现胃部症状。世界各地的研究人员正在积极开发新的药物传递系统(dds),如刺激反应性dds。这些载体对外部/内部甚至多种刺激的反应能力对于创造能够有效控制剂量、缓释、个体变化和靶向给药的“智能”DDS至关重要。为了对本文进行全面的文献调查,我们在“Google Scholar”、“NCBI”、“PubMed”和“Science Direct”等数据库/搜索引擎上检索了“刺激响应”、“COVID-19”和“药物递送”等术语。人们提出了许多不同类型的dds,包括响应各种外源(光、热、超声和磁场)或内源(pH、ROS和酶的微环境变化)刺激的dds。尽管DDS研究取得了重大进展,但必须解决几个具有挑战性的问题以填补文献中的空白。因此,本研究综述了内源性/外源性刺激反应性dds的药物释放机制和应用,同时探讨了它们在COVID-19中的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Smart stimuli-responsive drug delivery systems in spotlight of COVID-19

The world has been dealing with a novel severe acute respiratory syndrome (SARS-CoV-2) since the end of 2019, which threatens the lives of many people worldwide. COVID-19 causes respiratory infection with different symptoms, from sneezing and coughing to pneumonia and sometimes gastric symptoms. Researchers worldwide are actively developing novel drug delivery systems (DDSs), such as stimuli-responsive DDSs. The ability of these carriers to respond to external/internal and even multiple stimuli is essential in creating "smart" DDS that can effectively control dosage, sustained release, individual variations, and targeted delivery. To conduct a comprehensive literature survey for this article, the terms “Stimuli-responsive”, “COVID-19″ and “Drug delivery” were searched on databases/search engines like “Google Scholar”, “NCBI”, “PubMed”, and “Science Direct”. Many different types of DDSs have been proposed, including those responsive to various exogenous (light, heat, ultrasound and magnetic field) or endogenous (microenvironmental changes in pH, ROS and enzymes) stimuli. Despite significant progress in DDS research, several challenging issues must be addressed to fill the gaps in the literature. Therefore, this study reviews the drug release mechanisms and applications of endogenous/exogenous stimuli-responsive DDSs while also exploring their potential with respect to COVID-19.

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来源期刊
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
18.30
自引率
2.90%
发文量
11
审稿时长
14 days
期刊介绍: The Asian Journal of Pharmaceutical Sciences (AJPS) serves as the official journal of the Asian Federation for Pharmaceutical Sciences (AFPS). Recognized by the Science Citation Index Expanded (SCIE), AJPS offers a platform for the reporting of advancements, production methodologies, technologies, initiatives, and the practical application of scientific knowledge in the field of pharmaceutics. The journal covers a wide range of topics including but not limited to controlled drug release systems, drug targeting, physical pharmacy, pharmacodynamics, pharmacokinetics, pharmacogenomics, biopharmaceutics, drug and prodrug design, pharmaceutical analysis, drug stability, quality control, pharmaceutical engineering, and material sciences.
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