Maria C. Lucana, Roberta Lucchi, Fabien Gosselet, Cristina Díaz-Perlas and Benjamí Oller-Salvia
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BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium†
Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood–brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood–brain barrier.
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