戈瑞森根据气压波动调节雌性 C57BL/6J 小鼠的脑血流量

IF 3 3区医学 Q2 PHARMACOLOGY & PHARMACY Journal of pharmacological sciences Pub Date : 2023-12-07 DOI:10.1016/j.jphs.2023.12.001

Yuki Kurauchi , Sumika Ryu , Risako Tanaka , Makito Haruta , Kiyotaka Sasagawa , Takahiro Seki , Jun Ohta , Hiroshi Katsuki

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引用次数: 0

摘要

Goreisan 是一种用于治疗与气候变化有关的头痛的康波药物。在这里，我们通过使用植入式互补金属氧化物半导体（CMOS）装置，评估了高丽参和洛索洛芬对自由移动的小鼠中与气压波动相关的脑血流（CBF）动态的影响。在载体组中，气压降低会增加 CBF，而戈瑞散和洛索洛芬可阻止 CBF 的增加。值得注意的是，气压恢复后，戈瑞散（而不是洛索洛芬）会降低 CBF。这些结果表明，与解热镇痛药的作用机制不同，戈瑞散通过主动降低 CBF 的增加，使与气压波动相关的 CBF 异常恢复正常。

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Goreisan regulates cerebral blood flow according to barometric pressure fluctuations in female C57BL/6J mice

Goreisan is a Kampo medicine used to treat headaches associated with climate change. Here, by using an implantable complementary metal-oxide-semiconductor (CMOS) device, we evaluated the effects of Goreisan and loxoprofen on cerebral blood flow (CBF) dynamics associated with barometric pressure fluctuations in freely moving mice. In the vehicle group, decreasing barometric pressure increased CBF that was prevented by Goreisan and loxoprofen. Notably, Goreisan, but not loxoprofen, reduced CBF after returning to atmospheric pressure. These results indicate that, unlike the mechanism of action of antipyretic analgesics, Goreisan normalizes CBF abnormalities associated with barometric pressure fluctuations by actively reducing CBF increase.

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来源期刊

Journal of pharmacological sciences 医学-药学

CiteScore

6.20

自引率

2.90%

发文量

104

审稿时长

31 days

期刊介绍： Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.