炎性细胞因子是非感染性葡萄膜炎视网膜内皮屏障功能障碍的介质

IF 4.6 2区 医学 Q2 IMMUNOLOGY Clinical & Translational Immunology Pub Date : 2023-12-12 DOI:10.1002/cti2.1479
Lisia Barros Ferreira, Keryn A Williams, Giles Best, Cameron D Haydinger, Justine R Smith
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引用次数: 0

摘要

非感染性葡萄膜炎以眼内炎症为特征,包括一大类自身免疫性和自身炎症性疾病,这些疾病或仅累及眼部,或同时伴有眼部和全身表现。当非感染性葡萄膜炎累及眼球后段,特别是视网膜时,视力丧失的风险很大,这通常与内层血液-视网膜屏障的破坏有关。该屏障由非栅栏状视网膜血管内皮细胞形成,并由包括周细胞、Müller 细胞和星形胶质细胞在内的支持细胞加固。在已发表的文献中,有一组炎性细胞因子是眼内炎症的主要介质,它们对视网膜内皮的影响可能会导致内部血液-视网膜屏障的破坏,它们是肿瘤坏死因子 (TNF)-α、白细胞介素 (IL)-1β、IL-6、IL-8、IL-17 和趋化因子 C-C motif ligand (CCL)2。本文回顾了每种细胞因子的功能,并讨论了它们参与非感染性葡萄膜炎视网膜内皮屏障功能障碍的证据,包括基础实验室检查、对非感染性葡萄膜炎患者眼液的研究以及临床治疗试验的结果。综述还概述了这一领域的知识空白。从分子水平上了解疾病的过程,可以提出针对适当生物靶点的替代治疗方案,以保护非感染性葡萄膜炎患者的眼球后段和视力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non-infectious uveitis

Characterised by intraocular inflammation, non-infectious uveitis includes a large group of autoimmune and autoinflammatory diseases that either involve the eye alone or have both ocular and systemic manifestations. When non-infectious uveitis involves the posterior segment of the eye, specifically the retina, there is substantial risk of vision loss, often linked to breakdown of the inner blood-retinal barrier. This barrier is formed by non-fenestrated retinal vascular endothelial cells, reinforced by supporting cells that include pericytes, Müller cells and astrocytes. Across the published literature, a group of inflammatory cytokines stand out as prominent mediators of intraocular inflammation, with effects on the retinal endothelium that may contribute to breakdown of the inner blood-retinal barrier, namely tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8, IL-17 and chemokine C-C motif ligand (CCL)2. This article reviews the function of each cytokine and discusses the evidence for their involvement in retinal endothelial barrier dysfunction in non-infectious uveitis, including basic laboratory investigations, studies of ocular fluids collected from patients with non-infectious uveitis, and results of clinical treatment trials. The review also outlines gaps in knowledge in this area. Understanding the disease processes at a molecular level can suggest treatment alternatives that are directed against appropriate biological targets to protect the posterior segment of eye and preserve vision in non-infectious uveitis.

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来源期刊
Clinical & Translational Immunology
Clinical & Translational Immunology Medicine-Immunology and Allergy
CiteScore
12.00
自引率
1.70%
发文量
77
审稿时长
13 weeks
期刊介绍: Clinical & Translational Immunology is an open access, fully peer-reviewed journal devoted to publishing cutting-edge advances in biomedical research for scientists and physicians. The Journal covers fields including cancer biology, cardiovascular research, gene therapy, immunology, vaccine development and disease pathogenesis and therapy at the earliest phases of investigation.
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