电分析概述:传感中沙胺(5-氨基水杨酸)

IF 4.6 Q1 CHEMISTRY, ANALYTICAL ACS Measurement Science Au Pub Date : 2023-12-11 DOI:10.1021/acsmeasuresciau.3c00061
Robert D. Crapnell, Prashanth S. Adarakatti and Craig E. Banks*, 
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引用次数: 0

摘要

美沙拉明又称 5-氨基水杨酸,是一种主要用于治疗炎症性肠病(包括溃疡性结肠炎和克罗恩病)的药物。5- 氨基水杨酸可以使用各种台式实验室技术进行测量,其中包括液相色谱-质谱法,但这些技术都很复杂,而且体积庞大,这意味着它们不能在现场使用,因为可能会发生样品运输、化学品以及物理和生物反应,从而影响样品的成分,并可能导致结果不准确。另一种方法是使用基于电化学的传感平台,它具有便携、成本效益高、易于微型化和快速分析等优点,同时还具有灵敏度和选择性。我们概述了 5-氨基水杨酸传感电分析技术的使用情况,并将其与其他实验室测量方法进行了比较。本综述介绍了基于电分析的传感平台的应用、面临的挑战和未来的机遇。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Electroanalytical Overview: The Sensing of Mesalamine (5-Aminosalicylic Acid)

Mesalamine, known as 5-aminosalicylic acid, is a medication used primarily in the treatment of inflammatory bowel disease, including ulcerative colitis and Crohn’s disease. 5-Aminosalicylic acid can be measured using various benchtop laboratory techniques which involve liquid chromatography–mass spectroscopy, but these are sophisticated and large, meaning that they cannot be used on-site because transportation of the samples, chemicals, and physical and biological reactions can potentially occur, which can affect the sample’s composition and potentially result in inaccurate results. An alternative approach is the use of electrochemical based sensing platforms which has the advantages of portability, cost-efficiency, facile miniaturization, and rapid analysis while nonetheless providing sensitivity and selectivity. We provide an overview of the use of the electroanalytical techniques for the sensing of 5-aminosalicylic acid and compare them to other laboratory-based measurements. The applications, challenges faced, and future opportunities for electroanalytical based sensing platforms are presented in this review.

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来源期刊
ACS Measurement Science Au
ACS Measurement Science Au 化学计量学-
CiteScore
5.20
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0
期刊介绍: ACS Measurement Science Au is an open access journal that publishes experimental computational or theoretical research in all areas of chemical measurement science. Short letters comprehensive articles reviews and perspectives are welcome on topics that report on any phase of analytical operations including sampling measurement and data analysis. This includes:Chemical Reactions and SelectivityChemometrics and Data ProcessingElectrochemistryElemental and Molecular CharacterizationImagingInstrumentationMass SpectrometryMicroscale and Nanoscale systemsOmics (Genomics Proteomics Metabonomics Metabolomics and Bioinformatics)Sensors and Sensing (Biosensors Chemical Sensors Gas Sensors Intracellular Sensors Single-Molecule Sensors Cell Chips Arrays Microfluidic Devices)SeparationsSpectroscopySurface analysisPapers dealing with established methods need to offer a significantly improved original application of the method.
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