构建二氧化碳利用微生物平台底盘

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current Opinion in Systems Biology Pub Date : 2023-11-25 DOI:10.1016/j.coisb.2023.100489
Simona Della Valle, Weiming Tu, Wei E. Huang
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引用次数: 0

摘要

为实现循环生物经济,可通过微生物转化利用碳流生产增值化合物。虽然一些微生物能够自然地在这些可再生碳源上生长并产生理想的分子,但要开发出具有工业规模工艺所需的性能参数的平台底盘,还需要进行大量的工程设计。在此,我们简要概述了自养生物生产底盘工程的核心考虑因素,包括碳和能量供应,以及重新连接代谢途径以提高生长和生物合成能力的新兴标准。我们着重介绍了成功策略的实例,重点是本地自养生物和异养生物自养能力工程方面的最新进展。
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Construction of microbial platform chassis for CO2 utilisation

To achieve a circular bioeconomy, carbon streams can be utilised through microbial conversion to produce value-added compounds. Although some microorganisms are naturally able to grow on these renewable carbon sources and generate desirable molecules, significant engineering is required to develop platform chassis exhibiting attractive performance parameters for industrial-scale processes. Here, we provide a brief overview of the core considerations in chassis engineering for autotrophic bioproduction, including carbon and energy supply, in addition to emerging standards for rewiring metabolic pathways to enhance growth and biosynthetic capabilities. We highlight examples of successful strategies, placing emphasis on recent advances in engineering autotrophic capabilities in both native autotrophs and heterotrophs.

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来源期刊
Current Opinion in Systems Biology
Current Opinion in Systems Biology Mathematics-Applied Mathematics
CiteScore
7.10
自引率
2.70%
发文量
20
期刊介绍: Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution
期刊最新文献
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