晚期癌症患者口腔健康状况与生存时间的关系

Yoo Jeong Lee, In Cheol Hwang, Youn Seon Choi, Hong Yup Ahn, Eun Jeong Lee, Da Eun Kim
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摘要

癌症晚期患者经常会遇到各种各样的口腔问题。口腔健康状况是否与接受姑息治疗的晚期癌症患者的生存有关尚不清楚。我们使用改进的韩国版口腔健康评估工具(OHAT)分析了59名接受姑息治疗的韩国晚期癌症患者的数据,包括他们的口腔健康状况。根据OHAT评分将患者分为“良好”、“中等”或“较差”组。采用Kaplan-Meier法比较中位生存时间,采用Cox比例风险模型估计组间预后。最常见的口腔症状是口干(69.5%)和粘膜炎(17.0%)。高胆红素血症、肌酐水平升高和不使用假牙患者的生存时间明显缩短。口腔“差”组生存期短于口腔“好”组(P = 0.010)。多变量Cox比例风险分析显示,与“良好”组相比,“不良”组与不良生存率显著相关(风险比,2.05;P = .047)。口腔健康状况不佳的晚期癌症患者生存时间较短的风险较高。姑息治疗专业人员应注意口腔健康。需要进一步的研究来确定口腔护理对生存的影响。
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Association Between Oral Health Status and Survival Time in Terminally Ill Cancer Patients
Patients with terminal cancer often experience various oral problems. Whether oral health status is associated with the survival of terminally ill cancer patients receiving palliative care remains unclear. We analyzed the data of 59 Korean patients with terminal cancer receiving palliative care, including their oral health status, using a modified Korean version of the Oral Health Assessment Tool (OHAT). Patients were categorized into “Good,” “Moderate,” or “Poor” groups based on OHAT scores. The Kaplan-Meier method was used to compare the median survival time, and the prognosis between groups was estimated using Cox proportional hazard models. The most common oral symptoms observed were xerostomia (69.5%) and mucositis (17.0%). Significantly shorter survival times were observed in patients with hyperbilirubinemia, elevated creatinine levels, and no use of dentures. The “Poor” group had a shorter survival than the “Good” oral group ( P = .010). A multivariate Cox proportional hazards analysis revealed that the “Poor” group was significantly associated with poor survival compared to the “Good” group (hazard ratio, 2.05; P = .047). Terminally ill cancer patients with poor oral health may have a higher risk of shorter survival. Palliative care professionals should pay attention to oral health. Further research is needed to determine the effects of oral care on survival.
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Association Between Oral Health Status and Survival Time in Terminally Ill Cancer Patients Hospice news 2005 Cumulative subject index Hospice news Call for manuscripts
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