细胞外囊泡体内追踪技术的研究进展

Yanhua Shi, Xianghui Wang, Shifang Zhang, Hao Yin, Huaju Fan, Yaohui Tang, Nana Yang
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引用次数: 0

摘要

细胞有能力将细胞外囊泡(EVs)排出到一系列体液中。细胞外囊泡(Extracellular vesicles, EVs)包裹着蛋白质和核酸等生物分子,在促进细胞间通讯中起着重要作用。它们积极参与无数的生理和病理过程。在生物体中对ev的体内追踪有助于阐明ev为基础的治疗的生物学机制。分子成像技术的发展使在体内追踪电动汽车成为可能。实验经常使用一系列分子成像技术,包括生物发光成像、荧光成像、磁共振成像、单光子发射计算机断层扫描、正电子发射断层扫描、光声成像和多模态成像。这些方法各有优缺点。本文综述了ev体内追踪的典型应用。
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Research progress in in vivo tracing technology for extracellular vesicles
Cells have the capability to discharge extracellular vesicles (EVs) into a range of bodily fluids. Extracellular vesicles (EVs) encapsulate biological molecules such as proteins and nucleic acids, playing a role in facilitating cell-cell communication. They actively engage in a myriad of physiological and pathological processes. In vivo tracing of EVs in organisms significantly contributes to elucidating the biological mechanisms of EV-based therapy. The development of molecular imaging technology makes it possible to trace EVs in vivo . Experiments frequently employ a range of molecular imaging techniques, encompassing bioluminescence imaging, fluorescence imaging, magnetic resonance imaging, single photon emission computed tomography, positron emission tomography, photoacoustic imaging, and multimodal imaging. These methods have their own advantages and disadvantages. In this review, typical applications of in vivo tracing of EVs are reviewed.
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