M. Akbarpour, Mir Mohammad Jalali, Nafiseh Sadeghzadeh
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引用次数: 0
摘要
背景与目的:镁对耳郭的形态发生至关重要。耳膜化学成分的不平衡可使人易患良性阵发性位置性眩晕(BPPV)。主要结果是比较BPPV患者与对照组的血清镁水平。在本研究中,还记录和分析了参与者的Ca/Mg比率。方法:在本病例对照研究中,我们测量了BPPV患者和年龄、性别匹配的非BPPV患者的血清Mg、Ca和维生素D。研究结果根据钙、维生素D、高血压和体重指数进行了调整。结果:共有123例BPPV患者参与了本研究。患者的平均Mg值高于对照组(2.01 vs. 1.95 Mg /dL, p=0.030)。条件logistic回归分析显示,低钙/镁比(四分位数1)受试者的BPPV发生率高于中钙/镁比(四分位数2和3)受试者(校正OR: 3.92, p=0.003)。结论:BPPV患者存在Ca、Mg失衡,Mg水平明显升高,Ca/Mg比值明显降低。虽然Ca/Mg比降低似乎是BPPV的危险因素,但这一结果应在确证性研究中得到证实。关键词:镁;钙;良性阵发性位置性眩晕;otolithic膜;匹配配对分析
Blood Serum Levels of Magnesium in Patients with Benign Paroxysmal Positional Vertigo
Background and Aim: Magnesium is essential for the morphogenesis of otoconia. The imbalance in the chemical composition of otoconia can make people susceptible to Benign Paroxysmal Positional Vertigo (BPPV). The primary outcome was to compare serum magnesium levels in BPPV patients with controls. The Ca/Mg ratios in participants are also recorded and analyzed in the present study.
Methods: In this case-control study, we measured the serum Mg, Ca, and vitamin D in BPPV patients and age-, sex-matched subjects without BPPV. The results were adjusted for Ca, vitamin D, hypertension, and body mass index.
Results: A total of 123 BPPV patients participated in this study. The mean Mg value was higher in patients than controls (2.01 vs. 1.95 mg/dL, p=0.030). Condition logistic regression analyses showed a higher rate of BPPV among subjects with low Ca/Mg ratio (quartile 1), relative to subjects with medium ratio (quartiles 2 and 3) (adjusted OR: 3.92, p=0.003).
Conclusion: The present study demonstrated an imbalance of Ca and Mg in the BPPV patients as significantly higher Mg levels and lower serum Ca/Mg ratio. Although it appears decreased Ca/Mg ratio to be a risk factor for BPPV, this result should be confirmed in confirmatory studies.
Keywords: Magnesium; calcium; benign paroxysmal positional vertigo; otolithic membrane; matched-pair analysis