探索 COVID-19 的有效治疗方法:进展与前景综述

Oritoke M. Okeowo, Nzube F. Olung, O. Ijomone, Ayotunde S. Adeagbo
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摘要

由SARS-CoV-2冠状病毒引发的COVID-19大流行对全球卫生和经济造成了严重影响。这使得开发治疗COVID-19疾病的有效药物成为首要目标。在临床试验中,几种被重新用于治疗COVID-19的药物显示出了希望。尽管如此,在新冠病毒药物治疗的创造过程中,仍有许多障碍需要克服。由于COVID-19的病因不明,无法确定未来的治疗靶点是一个困难。另一个困难是病毒的快速进化,这可能导致产生耐药变种。此外,对有效疗法的强烈需求推动了临床试验的快速启动。由于对有效药物的强烈需求,临床试验过早开始,可能导致缺乏关于药物安全性和有效性的可靠数据。尽管存在这些障碍,但针对covid -19的各种有希望的药物治疗方法的开发取得了进展。这些药物包括免疫调节药物,如地塞米松和托珠单抗,以及抗病毒药物,如瑞德西韦和法匹拉韦。使用多种药物的联合治疗也可能有助于提高COVID-19患者的预后。尽管取得了一些令人鼓舞的进展,但在COVID-19药物治疗的开发过程中仍有许多障碍需要解决。需要进一步的研究来确定这种疾病最有效的治疗方法。
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Exploring Effective Therapeutic Approaches for COVID-19: A Review on Progress and Prospects
Global health and economy have been severely impacted by the COVID-19 pandemic that was brought on by the SARS-CoV-2 coronavirus. This makes the creation of potent medications for the treatment of COVID-19 disease a top goal. In clinical trials, several medications that have been repurposed for the treatment of COVID-19 have shown promise. Nevertheless, there are a lot of obstacles to overcome in the creation of COVID-19 pharmacological therapy. The inability to pinpoint prospective treatment targets is one difficulty caused by the unclear etiology of COVID-19. Another difficulty is the virus' quick evolution, which can result in the creation of drug-resistant variants. Furthermore, the quick start of clinical trials has been prompted by the strong demand for effective therapies. A lack of reliable data on the safety and efficacy of medications can result from the early start of clinical trials that have been prompted by the strong demand for effective medicines. Despite these obstacles, the development of various promising pharmacological treatments for COVID-19 has advanced. These include immune-modulating medications, like dexamethasone and tocilizumab, as well as antiviral medicines, like remdesivir and favipiravir. Combination therapies using several medications may also be useful in enhancing outcomes for COVID-19 patients. Despite some encouraging advancements, there are still a lot of obstacles to be addressed in the development of pharmacological therapy for COVID-19. Further research is needed to identify the most effective treatment approaches for this disease.
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