用药用植物 Sterculia foetida L 合成的生物银纳米粒子(AgNPs)对生物膜形成和细胞毒性的影响

IF 1 4区 材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY Digest Journal of Nanomaterials and Biostructures Pub Date : 2023-12-04 DOI:10.15251/djnb.2023.184.1503
N. Vasanth, T. Dons, L. J. Michaelraj, P. Ganesan, S. H. Salmen, S. A. Alharbi, S. Mutheeswaran, M. Anthonysamy, S. Ignacimuthu, A. Stalin
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引用次数: 0

摘要

本研究的主要实验分析是利用药用植物臭蹄草介导银纳米颗粒的生物合成。本研究最重要的目的和重点是通过生物学方法合成AgNPs,并对其生物膜形成和剂量依赖性细胞毒性进行了评价。体外综合分析表明,Ag比其他金属更具优势,植物残基介导了NPs。紫外光谱进一步表征NPs,在455nm处出现尖锐的吸收峰;通过FTIR等参数证明了相应功能截面的识别,其中确定了Ag离子和封盖剂的转化,X射线衍射分析证实了AgNPs的结晶性质和面心状立方结构。FESEM和EDAX显示了40-50nm的表面形貌。理化鉴定后,用生物膜形成和癌细胞对AgNPs进行评价。在细胞毒性研究中,以mcf7肺癌细胞系和A549乳腺癌细胞系为实验对象,其AgNPs值分别为(IC50 =11.50±0.05µg和5.5±0.05µg/mL);AgNO3- (IC50 = 5.8±0.05µg和6.5±0.05µg/mL)和Sterculia foetida (IC50 > 5000µg/mL和< 5000µg/mL)。本研究的另一个应用是抗生物膜测定。所选菌株为耐甲氧西林金黄色葡萄球菌;pa14 -铜绿假单胞菌和霍乱弧菌。因此,研究结果表明,药用植物鹿角银纳米颗粒是有效的,可以用于抗细菌,更准确地说,可以用于癌细胞研究。
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Effect of biofilm formation and cytotoxicity of biogenic silver nanoparticles (AgNPs) synthesized from a medicinal plant Sterculia foetida L.
The biogenic synthesis of silver nanoparticles mediated by medicinal plant Sterculia foetida was the prime experimental analysis of present study. The most important aim and focus of this study was to synthesis the AgNPs via biological method and the same had been evaluated against bio-film formation and dose dependent cyto-toxicity against cancer cells. This in vitro comprehensive analysis show that Ag had more advantage than other metals, the NPs was mediated by plant residue. And the NPs were further characterized by UV showing the sharp absorption peak at 455 nm; the identification of corresponding functional section proved by the parameter like FTIR, where conversion of Ag ions and capping agent is determined, the analysis on X- ray diffraction demonstrate the AgNPs found to be crystalline nature and face-centered like cubic structure. FESEM cum EDAX has showed the surface morphology with 40-50nm. After the physiochemical characterization, the AgNPs were evaluated with biofilm formation and cancer cells. In cyto-toxic study, two cell lines such as MCF 7 lung cancer cell line and A549 Breast cancer cell line were experimented and the values are AgNPs (IC50 =11.50± 0.05 µg and IC50 = 5.5± 0.05 µg/mL); AgNO3- (IC50 = 5.8± 0.05 µg and IC50 = 6.5± 0.05µg/mL) and Sterculia foetida (IC50 > 5000 µg/mL and IC50 < 5000 µg/mL). Another application of this present study is anti-biofilm assay. The selected bacterial strains are methicillinresistant Staphylococcus aureus; PA 14-Pseudomonas aeruginosa and Vibrio cholerae. Hence, the findings recommend that silver nanoparticles from medicinal plant Sterculia foetida is effective and can be used against bacteria and more precisely for cancer cell study.
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来源期刊
Digest Journal of Nanomaterials and Biostructures
Digest Journal of Nanomaterials and Biostructures 工程技术-材料科学:综合
CiteScore
1.50
自引率
22.20%
发文量
116
审稿时长
4.3 months
期刊介绍: Under the aegis of the Academy of Romanian Scientists Edited by: -Virtual Institute of Physics operated by Virtual Company of Physics.
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